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Titolo:
Fluoxetine versus placebo in depressed alcoholic cocaine abusers
Autore:
Cornelius, JR; Salloum, IM; Thase, ME; Haskett, RF; Daley, DC; Jones-Barlock, A; Upsher, C; Perel, JM;
Indirizzi:
Univsburgh,urgh, Med Ctr, Western Psychiat Inst & Clin, Dept Psychiat, Pitt Univ Pittsburgh Pittsburgh PA USA 15213 Inst & Clin, Dept Psychiat, Pitt
Titolo Testata:
PSYCHOPHARMACOLOGY BULLETIN
fascicolo: 1, volume: 34, anno: 1998,
pagine: 117 - 121
SICI:
0048-5764(1998)34:1<117:FVPIDA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC-DISORDERS; DOUBLE-BLIND; CLINICAL PRESENTATION; MAJOR DEPRESSION; SUICIDALITY; COMORBIDITY; PREVALENCE; SEVERITY; TRIAL;
Keywords:
fluoxetine; cocaine abuse; alcoholism; major depression; suicidality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cornelius, JR Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, DeptPsychiat, 3811 Univ Pittsburgh 3811 OHara St,Room 1092 Pittsburgh PA USA 15213
Citazione:
J.R. Cornelius et al., "Fluoxetine versus placebo in depressed alcoholic cocaine abusers", PSYCHOPH B, 34(1), 1998, pp. 117-121

Abstract

To date, few double-blind, placebo-controlled studies with any selective serotonin reuptake inhibitor (SSRI) antidepressant in pure cocaine abusers or in cocaine abusers with comorbid disorders have been reported. In this study, 17 patients with DSM-III-R diagnoses of major depressive disorder, alcohol dependence, and cocaine abuse were included along with 34 non-cocaine-abusing depressed alcoholics in a pharmacotherapy trial involving the SSRI antidepressant fluoxetine. All 51 patients participated in a double-blind, parallel group study of fluoxetine versus placebo in depressed alcoholics. The principal focus of this article is the one-third of the depressed alcoholics who also abused cocaine and how the treatment response of those 17 patients compared with that of the 34 depressed alcoholics who did not abuse cocaine. During the study, no significant difference in treatment outcome was noted between the fluoxetine group (N=8) and the placebo group (N=9) forcocaine use, alcohol use, or depressive symptoms. In addition, no significant within-group improvement was noted for any of these outcome variables in either of the two treatment groups. Indeed, across the combined sample of17 depressed alcoholic cocaine abusers, the mean Beck Depression Inventory(BDI) score worsened slightly from 19 to 21 during the course of the study, and 71 percent of the patients continued to complain of suicidal ideations at the end of the study. The 17 cocaine-abusing depressed alcoholics showed a significantly worse outcome than the 34 non-cocaine abusing depressed alcoholics on the 24-item Hamilton Rating Scale for Depression (HAM-D) and BDI depression scales and on multiple measures of alcohol consumption. These findings suggest that comorbid cocaine abuse acts as a robust predictor of poor outcome for the drinking and the depressive symptoms of depressed alcoholics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:59:41