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Titolo:
Naltrexone utility in depressed alcoholics
Autore:
Salloum, IM; Cornelius, JR; Thase, ME; Daley, DC; Kirisci, L; Spotts, C;
Indirizzi:
Univsburgh,urgh, Med Ctr, Western Psychiat Inst & Clin, Dept Psychiat, Pitt Univ Pittsburgh Pittsburgh PA USA 15213 Inst & Clin, Dept Psychiat, Pitt
Titolo Testata:
PSYCHOPHARMACOLOGY BULLETIN
fascicolo: 1, volume: 34, anno: 1998,
pagine: 111 - 115
SICI:
0048-5764(1998)34:1<111:NUIDA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; COMORBID MAJOR DEPRESSION; PSYCHIATRIC-DISORDERS; DOUBLE-BLIND; DEPENDENCE; FLUOXETINE; DYSPHORIA;
Keywords:
depressed alcoholics; treatment; Naltrexone; dual diagnosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Salloum, IM Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Dept Psychiat, 3811 Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 at, 3811
Citazione:
I.M. Salloum et al., "Naltrexone utility in depressed alcoholics", PSYCHOPH B, 34(1), 1998, pp. 111-115

Abstract

The aim of this open-label pilot study was to evaluate the utility of naltrexone (50 mg per day) in decreasing alcohol use and to examine its impact on depressive symptoms among depressed alcoholics who have failed to abstain from alcohol use despite treatment with a selective serotonin reuptake inhibitor (SSRI). Fourteen ambulatory care patients, aged 18 to 65 years, with DSM-III-R comorbid diagnoses of alcohol dependence and major depressive disorder, who failed to abstain despite treatment with an antidepressant medication were enrolled in the study, Patients were followed for 12 weeks with week ly assessment of drinking behavior, depressive symptoms, functioning, alcohol craving, and side effects. The results of this study indicated a significant decrease in alcohol use and in urges to drink alcohol in the presence of the usual triggers. There was also a trend suggesting improvement in depressive symptoms and overall functioning. Naltrexone was well tolerated, with mild side effects reported at the onset of treatment.

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Documento generato il 01/10/20 alle ore 06:54:31