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Titolo:
Long-term efficacy and safety comparison of sertindole and haloperidol in the treatment of schizophrenia
Autore:
Daniel, DG; Wozniak, P; Mack, RJ; McCarthy, BG;
Indirizzi:
Clin Studies Ltd, Falls Church, VA 22044 USA Clin Studies Ltd Falls Church VA USA 22044 td, Falls Church, VA 22044 USA Abbott Labs, Abbott Pk, IL 60064 USA Abbott Labs Abbott Pk IL USA 60064Abbott Labs, Abbott Pk, IL 60064 USA
Titolo Testata:
PSYCHOPHARMACOLOGY BULLETIN
fascicolo: 1, volume: 34, anno: 1998,
pagine: 61 - 69
SICI:
0048-5764(1998)34:1<61:LEASCO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEIGHT; CLOZAPINE; PROFILE;
Keywords:
schizophrenia; sertindole; neuroleptics; extrapyramidal symptoms; relapse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Daniel, DG Clin Studies Ltd, 6404-P 7 Corners Pl, Falls Church, VA 22044 USA Clin Studies Ltd 6404-P 7 Corners Pl Falls Church VA USA 22044
Citazione:
D.G. Daniel et al., "Long-term efficacy and safety comparison of sertindole and haloperidol in the treatment of schizophrenia", PSYCHOPH B, 34(1), 1998, pp. 61-69

Abstract

Sertindole is an atypical antipsychotic that is efficacious in schizophrenia and is associated infrequently with extrapyramidal symptoms(EPS), This study assessed time to treatment failure with 24 mg/day sertindole or 10 mg/day haloperidol in 282 clinically stable neuroleptic-responsive outpatientswith schizophrenia. During a 5-week transition period, patients were randomized to treatment with sertindole or haloperidol; other treatments were gradually discontinued. Patients then received treatment through Day 365. Time to treatment failure was numerically superior in sertindole-treated patients compared with haloperidol-treated patients, although this difference was not statistically significant, Sertindole-treated patients, however, remained free of hospitalization for exacerbation of schizophrenia and remainedmedically compliant significantly longer than did haloperidol-treated patients. In addition, there were significantly fewer reports of EPS in sertindole-treated patients and sertindole therapy was generally well tolerated. Patients transitioned well from other antipsychotic agents to sertindole, Sertindole appears to be an effective long-term treatment for schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:30:04