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Titolo:
GR 127935 reduces basal locomotor activity and prevents RU 24969-, but notD-amphetamine induced hyperlocomotion, in the Wistar-Kyoto Hyperactive (WKHA) rat
Autore:
Chaouloff, F; Courvoisier, H; Moisan, MP; Mormede, P;
Indirizzi:
Inst F Magendie, INSERM, U471, F-33077 Bordeaux, France Inst F Magendie Bordeaux France F-33077 , U471, F-33077 Bordeaux, France
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 141, anno: 1999,
pagine: 326 - 331
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1 RECEPTOR AGONIST; SEROTONIN RELEASE; BEHAVIOR; RU-24969; STRAINS; ANTIDEPRESSANTS; ACTIVATION; 5HT(1A); MICE;
Keywords:
RU 24969; GR 127935; 5-HT1B,D receptor; D-amphetamine; locomotor activity; rearing; WKHA rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Chaouloff, F Instce Magendie, INSERM, U471, Rue Camille St Saens, F-33077 Bordeaux, Fran Inst F Magendie Rue Camille St Saens Bordeaux France F-33077
Citazione:
F. Chaouloff et al., "GR 127935 reduces basal locomotor activity and prevents RU 24969-, but notD-amphetamine induced hyperlocomotion, in the Wistar-Kyoto Hyperactive (WKHA) rat", PSYCHOPHAR, 141(3), 1999, pp. 326-331

Abstract

The hyperlocomotor effect of the serotonin (5-HT)(1A,B) receptor agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)- 1H-indole (RU 24969) has been repeatedly reported. However, 5-HT1A receptors, 5-HT1B receptors (or both) have been claimed to mediate this effect of RU 24969. These contradictory data possibly arise from protocol differences, especially those related to animal species, drugs, and activity assessment. Herein, the influence of a pretreatment with the selective 5-HT1B,D receptor antagonist N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiozol-3-yl)-biphenyl-4-carboxamide (GR 127935; 1, 3.3 and 10 mg/kg IP) on the hyperlocomotor effect of a 5 mg/kg (IP) dose of RU 24969 was studied in Wistar-Kyoto Hyperactive (WKHA) rats. In a first series of experiments, it was confirmed that RU 24969 (2.5 and 5 mg/kg), administered 10 min after the onset ofactivity recordings, increases locomotion dose-dependently (cage crossings). In a second series of experiments, administration of GR 127935 10 min after the onset of activity recordings promoted a dose-dependent decrease in basal activity (and rearings) and prevented (3.3 and 10 mg/kg) RU 24969-elicited locomotor activity. On the other hand, GR 127935 was ineffective against RU 24969-induced inhibition of rearings. Lastly, it was observed that 3.3 mg/kg GR 127935 did not affect the number of cage crossings and rearingsdisplayed by rats administered 1.5 mg/kg D-amphetamine. This study shows that 5-HT1B receptors play a major role in the hyperlocomotor effect of RU 24969, at least under our experimental setting. Whether these receptors alsoplay a tonic role in the high locomotor activity displayed by WKHA rats remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:59:29