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Titolo:
RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist
Autore:
Harrison, AA; Parsons, LH; Koob, GF; Markou, A;
Indirizzi:
Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 col, La Jolla, CA 92037 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 141, anno: 1999,
pagine: 242 - 250
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACRANIAL SELF-STIMULATION; PROGRESSIVE RATIO SCHEDULE; DISCRIMINATIVE STIMULUS PROPERTIES; NUCLEUS-ACCUMBENS; BINDING-SITES; D-AMPHETAMINE; GUINEA-PIG; ACETYLCHOLINE-RELEASE; 5-HT AUTORECEPTORS; DOPAMINE RELEASE;
Keywords:
5-HT1B; RU 24969; GR 127935; intracranial self-stimulation; reward; cocaine; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Harrison, AA Scripps,Clin & Res Inst, Dept Neuropharmacol, CVN-7,10550 N Torrey Pines Rd Scripps Clin & Res Inst CVN-7,10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
A.A. Harrison et al., "RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist", PSYCHOPHAR, 141(3), 1999, pp. 242-250

Abstract

Recent studies suggest that serotonergic neurotransmission through the serotonin-1B (5-HT1B) receptor is involved in reward processes. The purpose ofthe present studies was to investigate the effects of 5-HT1B receptor activation and antagonism on intracranial self-stimulation (ICSS) reward using a current-threshold ICSS task. Male Wistar rats were prepared with bipolar electrodes in the lateral hypothalamus. When stable baseline thresholds were established, the effects of the mixed 5-HT1A/1B receptor agonist, RU 24969 (0-1 mg/kg, SC), on ICSS behavior were assessed. Administration of this compound elevated ICSS thresholds without affecting response latencies, a measure of general motoric activity. The 5-HT1B/1D receptor antagonist, GR 127935 (0-10 mg/kg, SC), had no significant effect on ICSS behavior. However,pretreatment with an intermediate dose of GR 127935 (3 mg/kg), which was previously without effect on ICSS behavior, reversed the threshold-elevatingeffects of RU 24969 (1 mg/kg), suggesting the involvement of the 5-HT1B receptor in this effect of RU 24969 administration. Furthermore, pretreatmentwith RU 24969 (0.3 and 0.6 mg/kg), prior to 10 mg/kg cocaine hydrochloride, dose-dependently attenuated the threshold-reducing effects of cocaine. This result is interpreted as two opposing drug effects canceling each other out rather than a specific pharmacological antagonism. In conclusion, the results suggest that activation of 5-HT1B receptors reduces brain stimulation reward.

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Documento generato il 02/12/20 alle ore 15:23:28