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Titolo:
Renin secretion from permeabilized juxtaglomerular cells requires a permeant cation
Autore:
Jensen, BL; Ellekvist, P; Skott, O;
Indirizzi:
Odense Univ, Dept Physiol, DK-5000 Odense, Denmark Odense Univ Odense Denmark DK-5000 Dept Physiol, DK-5000 Odense, Denmark
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 3, volume: 437, anno: 1999,
pagine: 449 - 454
SICI:
0031-6768(199902)437:3<449:RSFPJC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM-TRANSPORT; ANGIOTENSIN-II; CHLORIDE-IONS; RELEASE; CALCIUM; PLASMA; EXOCYTOSIS; MEMBRANE; ACINI;
Keywords:
anion; cation; channel; chloride; exocytosis; granule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Skott, O Odense Univ, Dept Physiol, Winslowparken 19, DK-5000 Odense, Denmark Odense Univ Winslowparken 19 Odense Denmark DK-5000 nse, Denmark
Citazione:
B.L. Jensen et al., "Renin secretion from permeabilized juxtaglomerular cells requires a permeant cation", PFLUG ARCH, 437(3), 1999, pp. 449-454

Abstract

The cytosolic concentration of chloride correlates directly with renin secretion from renal juxtaglomerular granular (JG) cells. In the present study, the mechanism by which chloride stimulates renin release was investigatedin a preparation of permeabilized rat glomeruli with attached JG cells. Anisosmotic increase in the concentration of chloride by 129 mM stimulated renin release 16- to 20-fold. Substitution of K+ by the impermeant cation N-methyl-D-glucamine (NMDG) abolished this response, while substitution with Na+ caused marginal inhibition. Substitution with Cs+ had no effect. Addition of sucrose, which permeates the secretory granules poorly, also abolished the stimulation of renin secretion by KCl. The response to KCl was not affected by K+-channel antagonists or by agonists of K+ channels. Chloride channel blockers were also without effect on the secretory response to KCl. When the ATP concentration was lowered from 1 to 0.1 mM renin release was stimulated, while an increase in the ATP concentration from 1 to 5 mM had no effect. Blockers of ATP-sensitive (K-ATP) channels did not modify the response to chloride. The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results inswelling and release of renin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:36:15