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Titolo:
Scopolamine enhances middle-latency auditory evoked magnetic fields
Autore:
Jaaskelainen, IP; Hirvonen, J; Huttunen, J; Kaakkola, S; Pekkonen, E;
Indirizzi:
Univlandsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Fin Univ Helsinki Helsinki Finland FIN-00014 s Unit, FIN-00014 Helsinki, Fin Univlandsinki, Cent Hosp, Med Engn Ctr, BioMag Lab, FIN-00029 Helsinki, Fin Univ Helsinki Helsinki Finland FIN-00029 ag Lab, FIN-00029 Helsinki, Fin Univ Helsinki, Cent Hosp, Dept Clin Neurosci, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ci, FIN-00029 Helsinki, Finland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 259, anno: 1999,
pagine: 41 - 44
SICI:
0304-3940(19990104)259:1<41:SEMAEM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTEX; POTENTIALS; RESPONSES; LESIONS; DISEASE; BRAIN;
Keywords:
scopolamine; magnetoencephalography; middle-latency auditory evoked potentials; middle-latency auditory evoked magnetic fields; acetylcholine; muscarinic transmission; auditory cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Jaaskelainen, IP Univnki,sinki, Dept Psychol, Cognit Brain Res Unit, POB 13, FIN-00014 Helsi Univ Helsinki POB 13 Helsinki Finland FIN-00014 14 Helsi
Citazione:
I.P. Jaaskelainen et al., "Scopolamine enhances middle-latency auditory evoked magnetic fields", NEUROSCI L, 259(1), 1999, pp. 41-44

Abstract

To study the influence of central cholinergic muscarinic transmission on human cortical middle-latency auditory evoked magnetic fields (MAEF), centrally acting antagonist scopolamine hydrobromide (0.3 mg, i.v.), and peripheral muscarinic receptor antagonist glycopyrrolate (0.2 mg, i.v.),were administered to 13 healthy subjects in a double-blind randomized cross-over design. MAEF, measured with whole-head magnetoencephalography (MEG), were elicited with clicks applied at 10-Hz rate to the left ear. The amplitudes of N(b)m and P(a)m responses were augmented by scopolamine (P < 0.01 and P < 0.08). These effects were about equally strong for responses from ipsi- and contralateral auditory cortices. Thus, the present MEG findings revealed specific modulation of cortical generators of middle-latency auditory evoked responses by muscarinic transmission. These findings might be associated with auditory processing deficits observed in dementias with cholinergic disturbances. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:18:15