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Titolo:
Argyrophilic glial inclusions in the midbrain of patients with Parkinson'sdisease and diffuse Lewy body disease are immunopositive for NACP/alpha-synuclein
Autore:
Arai, T; Ueda, K; Ikeda, K; Akiyama, H; Haga, C; Kondo, H; Kuroki, N; Niizato, K; Iritani, S; Tsuchiya, K;
Indirizzi:
Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, Japan Inst Psychiat Tokyo Japan 1568585 hol, Setagaya Ku, Tokyo 1568585, Japan Inst Psychiat, Dept Neurochem, Setagaya Ku, Tokyo 1568585, Japan Inst Psychiat Tokyo Japan 1568585 hem, Setagaya Ku, Tokyo 1568585, Japan Toky Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan Toky Metropolitan Matsuzawa Hosp Tokyo Japan 1560057 okyo 1560057, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 259, anno: 1999,
pagine: 83 - 86
SICI:
0304-3940(19990108)259:2<83:AGIITM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAU-PROTEIN; BRAIN; GENE;
Keywords:
oligodendroglia; aggregate; multiple system atrophy; glial cytoplasmic inclusion; tau; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, T Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, JapanInst Psychiat Tokyo Japan 1568585 agaya Ku, Tokyo 1568585, Japan
Citazione:
T. Arai et al., "Argyrophilic glial inclusions in the midbrain of patients with Parkinson'sdisease and diffuse Lewy body disease are immunopositive for NACP/alpha-synuclein", NEUROSCI L, 259(2), 1999, pp. 83-86

Abstract

Argyrophilic glial inclusions occur in the midbrain of patients with Parkinson's disease (PD) and diffuse Lewy body disease (DLBD). These inclusions are immunohistochemically positive for NACP/alpha-synuclein but negative for tau protein. The results of the present study suggest that a primary degenerative process involves NACP/alpha-synuclein in PD and DLBD and that the process takes place not only in neurons but also in glial cells. Argyrophilic cytoplasmic inclusions, both glial and neuronal, in a variety of degenerative diseases may be grouped into two major categories; one related to aggregates of abnormally phosphorylated tau protein and the other to unusual accumulations of NACP/alpha-synuclein. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:47:03