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Titolo:
Auditory P50 in schizophrenics on clozapine: Improved gating parallels clinical improvement and changes in plasma 3-methoxy-4-hydroxyphenylglycol
Autore:
Nagamoto, HT; Adler, LE; McRae, KA; Huettl, P; Cawthra, E; Gerhardt, G; Hea, R; Griffith, J;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Dept Psychiat, Denver, CO 80262 USA Denver Vet Affairs Med Ctr, Dept Psychiat, Denver, CO USA Denver Vet Affairs Med Ctr Denver CO USA , Dept Psychiat, Denver, CO USA
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 1, volume: 39, anno: 1999,
pagine: 10 - 17
SICI:
0302-282X(1999)39:1<10:APISOC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE METABOLISM; TREATMENT RESPONSE; NEUROPHYSIOLOGICAL EVIDENCE; PSYCHIATRIC-INPATIENTS; HALOPERIDOL TREATMENT; STIMULATION INTERVAL; CEREBROSPINAL-FLUID; NOREPINEPHRINE; PSYCHOSIS; DEFICIT;
Keywords:
auditory evoked potential; schizophrenia; clozapine; sensory gating; 3-methoxy-4-hydroxyphenylglycol; homovanillic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, LE Univ,Colorado, Hlth Sci Ctr, Dept Psychiat, C-268-71,4200 E 9th Ave, Denver Univ Colorado C-268-71,4200 E 9th Ave Denver CO USA 80262 Denver
Citazione:
H.T. Nagamoto et al., "Auditory P50 in schizophrenics on clozapine: Improved gating parallels clinical improvement and changes in plasma 3-methoxy-4-hydroxyphenylglycol", NEUROPSYCHB, 39(1), 1999, pp. 10-17

Abstract

Schizophrenic patients have decreased inhibition of the P50 auditory evoked potential response to the second of two paired click stimuli delivered 500 ms apart. This deficit in inhibitory gating does not change during treatment with typical neuroleptics. We recently reported that neuroleptic-resistant schizophrenics had enhanced P50 gating after 1 month of clozapine treatment, if they responded with decreased clinical symptoms. This study reports the outcome of more prolonged treatment. Ten treatment-refractory schizophrenic patients were studied at baseline, after 1 month on clozapine, and again after 15 +/- 6.1 (SD) months of clozapine treatment. Eight subjects reached a clinically stable improved state, at which time they had significantly improved P50 auditory gating. One patient had a return of impaired gating after stopping clozapine, as did another during a clinical relapse. Decreasing plasma 3-methoxy-4-hydroxyphenylglycol levels with clozapine treatment were correlated with improved P50 gating and improved Brief Bsychiatric Rating Scale-positive scores. This study provides further evidence that improved P50 gating in schizophrenic patients treated with clozapine coincideswith clinical improvement and that this improvement can be sustained for at least 1 year.

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Documento generato il 22/01/20 alle ore 12:52:59