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Titolo:
Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain
Autore:
Abe, S; Hori, T; Suzuki, T; Baba, A; Shiraishi, H; Yamamoto, T;
Indirizzi:
Univ Tsukuba, Dept Psychiat, Inst Clin Med, Ibaraki, Osaka 3058575, Japan Univ Tsukuba Ibaraki Osaka Japan 3058575 d, Ibaraki, Osaka 3058575, Japan Yokohamapanty Univ, Grad Sch Integrated Sci, Lab Mol Recognit, Kanagawa, Ja Yokohama City Univ Kanagawa Japan d Sci, Lab Mol Recognit, Kanagawa, Ja
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 3, volume: 24, anno: 1999,
pagine: 359 - 363
SICI:
0364-3190(199903)24:3<359:EOCAOI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; CORTICAL MEMBRANES; STIMULATION; FLUOXETINE; DEPRESSION; SECRETION; BARRIER; CORTEX; LIGAND; 5-HT1A;
Keywords:
interferon; neuropsychiatric complications; depression; serotonin; 5-HT7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Univ Tsukuba, Dept Psychiat, Inst Clin Med, 1-1-1 Tennoudai, Ibaraki, Osaka Univ Tsukuba 1-1-1 Tennoudai Ibaraki Osaka Japan 3058575 , Osaka
Citazione:
S. Abe et al., "Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain", NEUROCHEM R, 24(3), 1999, pp. 359-363

Abstract

The effects of chronic administration of interferon (IFN; recombinant human IFN -alpha A/D) on serotonergic binding sites in rat brain were investigated. IFN was injected daily for 2 weeks at a dose of 100000 I.U./kg, (i.p.)in male Wistar rats. IFN did not alter either [H-3]ketanserin binding to 5-HT2A receptors or [H-3]paroxetine binding to 5-HT transporters. Scatchard analysis of [H-3]8-hydroxy-dipropylaminotelraline (8-OH-DPAT) binding to 5-HT1A receptors demonstrated the presence of high- and low-affinity binding sites in both treatment and control groups. IFN significantly increased both Kd and Bmax measures of [H-3]8-OH-DPAT binding at low-affinity binding sites, but not at the high-affinity sites. These results suggest that IFN affects the low-affinity 5-HT1A receptors sites and may be involved in the development of IFN-induced psychiatric disturbances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:53:17