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Titolo:
Brain cannabinoid systems as targets for the therapy of neurological disorders
Autore:
Consroe, P;
Indirizzi:
Univ Arizona, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USAUniv Arizona Tucson AZ USA 85721 harmacol & Toxicol, Tucson, AZ 85721 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 6, volume: 5, anno: 1998,
pagine: 534 - 551
SICI:
0969-9961(199812)5:6<534:BCSATF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONIST SR 141716A; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NIGRA PARS RETICULATA; PIG SMALL-INTESTINE; RECEPTOR ANTAGONIST; SUBSTANTIA-NIGRA; RAT-BRAIN; MULTIPLE-SCLEROSIS; HUNTINGTONS-DISEASE; GLOBUS-PALLIDUS;
Keywords:
cannabis; cannabinoids; cannabinoid receptor; marijuana; neurological disorders;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
159
Recensione:
Indirizzi per estratti:
Indirizzo: Consroe, P Univ Arizona, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 Toxicol, Tucson, AZ 85721 USA
Citazione:
P. Consroe, "Brain cannabinoid systems as targets for the therapy of neurological disorders", NEUROBIOL D, 5(6), 1998, pp. 534-551

Abstract

Unprecedented developments in cannabinoid research within the past decade include discovery of a brain (CB1) and peripheral (CB2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at CB1 receptors, antagonism of NMDA receptors and glutamate, and antioxidant activity; and preferential CB1 receptor localization in areas subserving spasticity, pain, abnormal involuntary movements, seizures, and amnesia. These endogenous structures and chemicals and mechanisms are potentially new pathophysiologic substrates, and targets for novel cannabinoid treatments, of several neurological disorders, (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:24:03