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Titolo:
Biochemistry of the endogenous ligands of cannabinoid receptors
Autore:
Di Marzo, V; Deutsch, DG;
Indirizzi:
CNR, Ist Chim Mol Interesse Biol, I-80072 Arco Felice, Naples, Italy CNR Arco Felice Naples Italy I-80072 , I-80072 Arco Felice, Naples, Italy SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA SUNYStony Brook Stony Brook NY USA 11794 Biol, Stony Brook, NY 11794 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 6, volume: 5, anno: 1998,
pagine: 386 - 404
SICI:
0969-9961(199812)5:6<386:BOTELO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE NEUROBLASTOMA-CELLS; FATTY-ACID ETHANOLAMIDES; RAT-BRAIN MICROSOMES; ADENYLATE-CYCLASE INHIBITION; HYBRID NG108-15 CELLS; ANANDAMIDE AMIDOHYDROLASE; MOLECULAR CHARACTERIZATION; ENZYMATIC-SYNTHESIS; ARACHIDONIC-ACID; PHARMACOLOGICAL ACTIVITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Di Marzo, V CNR,,Ist Chim Mol Interesse Biol, Via Toiano 6, I-80072 Arco Felice, Naples CNR Via Toiano 6 Arco Felice Naples Italy I-80072 lice, Naples
Citazione:
V. Di Marzo e D.G. Deutsch, "Biochemistry of the endogenous ligands of cannabinoid receptors", NEUROBIOL D, 5(6), 1998, pp. 386-404

Abstract

In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an "endogenous cannabinoid regulatory system" exists in mammalian nervous tissue. Anandamide (N-arachidonoyl-ethanolamine) was the first of a series of long-chain fatty acid derivatives, including two other polyunsaturated N-acylethanolamines and 2-arachidonoyl-glycerol, found to exert cannabimimetic properties in either central or peripheral tissues. Here we review the current knowledge on the biochemical bases of the formation and inactivation of endogenous cannabinoid ligands as well as of their interaction with cannabinoidreceptor subtypes. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:37:21