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Titolo:
Poor renal accumulation of Tc-99m-DMSA in idiopathic tubular proteinuria
Autore:
Suzuki, S; Suzuki, J; Kume, K; Yoshida, K; Suyama, H; Kawasaki, Y; Nozawa, R; Suzuki, H; Fujiki, T; Kamiyama, S; Suzuki, A;
Indirizzi:
Fukushima Med Univ, Dept Pediat, Fukushima 9601295, Japan Fukushima Med Univ Fukushima Japan 9601295 iat, Fukushima 9601295, Japan Fukushima Med Univ, Dept Radiol, Fukushima 9601295, Japan Fukushima Med Univ Fukushima Japan 9601295 iol, Fukushima 9601295, Japan Takeda Gen Hosp, Aizuwakamatsu, Japan Takeda Gen Hosp Aizuwakamatsu Japan keda Gen Hosp, Aizuwakamatsu, Japan Kureha Gen Hosp, Iwaki, Fukushima, Japan Kureha Gen Hosp Iwaki Fukushima Japan Gen Hosp, Iwaki, Fukushima, Japan
Titolo Testata:
NEPHRON
fascicolo: 1, volume: 81, anno: 1999,
pagine: 49 - 54
SICI:
0028-2766(199901)81:1<49:PRAOTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT PROTEINURIA; JAPANESE CHILDREN; CLCN5; NEPHROCALCINOSIS; MUTATIONS; DMSA; HYPERCALCIURIA; DYSFUNCTION; DISEASE; AGENTS;
Keywords:
idiopathic tubular proteinuria; Tc-99m-DMSA; proximal tubular dysfunction; beta(2)-microglobulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, S Fukushima Med Univ, Dept Pediat, Hikarigaoka 1, Fukushima 9601295, Japan Fukushima Med Univ Hikarigaoka 1 Fukushima Japan 9601295 Japan
Citazione:
S. Suzuki et al., "Poor renal accumulation of Tc-99m-DMSA in idiopathic tubular proteinuria", NEPHRON, 81(1), 1999, pp. 49-54

Abstract

In Japanese patients idiopathic tubular proteinuria presents mainly as asymptomatic tubular low molecular weight proteinuria. This disease has recently been shown to resemble Dent's disease which is characterized by tubular proteinuria, hypercalciuria, rickets and eventual renal failure. We report on 4 children with idiopathic tubular proteinuria. Although they had normalrenal function, as evidenced by serum creatinine or creatinine clearance, they had very poor renal accumulation of Tc-99m-DMSA and the presence of large amounts of tracer in the bladder. Additionally, the patient with the largest amounts of tubular proteinuria had the poorest renal accumulation of the 4 patients. The renal accumulation of tracer decreased with time from amaximum at 10 min after injection. These findings demonstrate that the tracer, once taken to be confined to the proximal tubular cells, is immediately excreted to the tubular lumen. We suggest that poor renal accumulation ofTc-99m-DMSA is very important in elucidating the mechanism of idiopathic tubular proteinuria, and that Tc-99m-DMSA renoscintigraphy is useful in the evaluation of the patient's renal function over time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:51:43