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Titolo:
Anxiolytic 5-hydroxytryptamine(1A) agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: Single-unit study in unanesthetized, unrestrained rats
Autore:
Tada, K; Kasamo, K; Ueda, N; Suzuki, T; Kojima, T; Ishikawa, K;
Indirizzi:
Nihon Univ, Sch Med, Dept Neuropsychiat, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Dept Neuropsychiat, Tokyo 1738610, Japan Nihon Univ, Sch Med, Dept Pharmacol, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Med, Dept Pharmacol, Tokyo 1738610, Japan
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 2, volume: 288, anno: 1999,
pagine: 843 - 848
SICI:
0022-3565(199902)288:2<843:A5ASFA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A AGONIST; BEHAVING CATS; BRAIN MICRODIALYSIS; CONDITIONED FEAR; RECEPTOR RESERVE; CEREBRAL-CORTEX; RAPHE NEURONS; SEROTONIN; ANTAGONISTS; NAN-190;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Tada, K Nihon8610,, Sch Med, Dept Neuropsychiat, Oyaguchi Kamimachi 30-1, Tokyo 173 Nihon Univ Oyaguchi Kamimachi 30-1 Tokyo Japan 1738610 Tokyo 173
Citazione:
K. Tada et al., "Anxiolytic 5-hydroxytryptamine(1A) agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: Single-unit study in unanesthetized, unrestrained rats", J PHARM EXP, 288(2), 1999, pp. 843-848

Abstract

Recent behavioral studies indicate that conditioned fear response to contextual stimuli is reduced effectively by anxiolytic 5-hydroxytryptame (5-HT)(1A) agonists. Since the hippocampus seems to play an essential role in associative fear memories evoked by context, it is important to assess the effect of 5-HT1A agonists on pyramidal cell activity in the hippocampus. We examined the effects of 5-HT1A agonists on the spontaneous firing rate of hippocampal CA1 pyramidal neurons in unanesthetized, unrestrained rats. Systemic administration of selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin, buspirone, ipsapirone, and flesinoxan produced a dose-dependent inhibition of neuronal activity. Putative 5-HT1A antagonists NAN-190 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine and (-)-pindolol did not change neuronal activity of CA1 pyramidal neurons. The suppression of neuronal activity by buspirone was antagonized by NAN-190 but not by (-)-pindolol. Lack of antagonistic activity of (-)pindolol for the suppression of pyramidal neurons via a postsynaptic mechanism is consistent with the results of recent electrophysiological experiments in anesthetized rats. Pretreatment with parachlorphenylalanine did not change the spontaneous firing rates of hippocampal CA1 pyramidal neurons or abolish the suppressant effects of buspirone on these neurons. Taken together, the present results strongly suggest that suppression of the hippocampal CA1 pyramidal neuronal activityby anxiolytic 5-HT1A agonists in awake rats is mediated by postsynaptic 5-HT1A receptors located on pyramidal neurons.

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Documento generato il 25/01/20 alle ore 16:15:24