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Titolo:
Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis
Autore:
Karachunski, PI; Ostlie, NS; Okita, DK; Garman, R; Conti-Fine, BM;
Indirizzi:
Univ Minnesota, Dept Biochem, Coll Biol Sci, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Coll Biol Sci, St Paul, MN 55108 USA Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA ImmuLog Pharmaceut, Waltham, MA 02154 USA ImmuLog Pharmaceut Waltham MA USA 02154 Pharmaceut, Waltham, MA 02154 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 93, anno: 1999,
pagine: 108 - 121
SICI:
0165-5728(19990101)93:1-2<108:SAOTSO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ORAL TOLERANCE; IFN-GAMMA; CELL PROLIFERATION; ANTIGEN; MECHANISMS; INDUCTION; MUTATION; IL-10; MICE;
Keywords:
acetylcholine receptor; experimental myasthenia gravis; Th2 cells; subcutaneous tolerance; autoimmunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ55108esota, Dept Biochem, Coll Biol Sci, 1479 Gortner Ave, St Paul, MN Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 ul, MN
Citazione:
P.I. Karachunski et al., "Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis", J NEUROIMM, 93(1-2), 1999, pp. 108-121

Abstract

Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis (EMG). The s.c. administration to C57BI/6 mice of synthetic AChR CD4(+) epitopes, before and during AChR immunization, reduced the epitope-specific CD4(+) responses and the anti-AChR Ab synthesis, and prevented EMG. The s.c. administration of solubilized AChR had effects similar to thoseof peptide treatment. Sham-tolerized mice had only Thl anti-AChR cells, whereas peptide-treated mice had also Th2, cells, and Th2-induced anti-peptide Ab. Established EMG was not affected by s.c. peptide treatment, whereas it worsened after s.c. administration of solubilized AChR. (C) 1999 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:40:09