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Titolo:
Timing and casting for actors of thymic negative selection
Autore:
Dautigny, N; Le Campion, A; Lucas, B;
Indirizzi:
Inst Necker, INSERM, U345, F-75730 Paris 15, France Inst Necker Paris France 15 cker, INSERM, U345, F-75730 Paris 15, France
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 162, anno: 1999,
pagine: 1294 - 1302
SICI:
0022-1767(19990201)162:3<1294:TACFAO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TRANSGENIC MICE; PERIPHERAL T-CELLS; INTERCELLULAR-ADHESION MOLECULE-1; P56(LCK) TYROSINE KINASE; ANTIGEN-PRESENTING CELLS; CLASS-II MHC; CLONAL DELETION; POSITIVE SELECTION; DENDRITIC CELLS; B-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas, B Inst Necker, INSERM, U345, 156 Rue Vaugirard, F-75730 Paris 15, France Inst Necker 156 Rue Vaugirard Paris France 15 0 Paris 15, France
Citazione:
N. Dautigny et al., "Timing and casting for actors of thymic negative selection", J IMMUNOL, 162(3), 1999, pp. 1294-1302

Abstract

We have recently proposed a new model for the differentiation pathway of alpha beta TCR thymocytes, with the CD4 and CD8 coreceptors undergoing an unexpectedly complex series of expression changes. Taking into account this new insight, we reinvestigated the timing of thymic negative selection, We found that, although endogenous superantigen driven thymic negative selection could occur at different steps during double-positive/single-positive cell transition, this event was never observed among CD4(low)CD8(low) TCRint CD69(+) thymocytes, i.e., within the first subset to be generated upon TCR-mediated activation of immature double-positive cells. We confirm a role forCD40/CD40L interaction, and the absence of involvement of CD28 costimulation, in thymic deletion in vivo. Surprisingly, we found that thymic negativeselection was impaired in the absence of Fas, but not Fast, molecule expression, Finally, we show involvement in opposing directions for p59(fyn) andSHP-1 molecules in signaling for thymic negative selection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:19:26