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Titolo:
Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent gadobutrol
Autore:
Hofmann, B; Fischer, CO; Lawaczeck, R; Platzek, J; Semmler, W;
Indirizzi:
Inst Diagnost Forsch GmbH, D-14050 Berlin, Germany Inst Diagnost Forsch GmbH Berlin Germany D-14050 D-14050 Berlin, Germany Hahn Meitner Inst Kernforsch Berlin GmbH, D-1000 Berlin, Germany Hahn Meitner Inst Kernforsch Berlin GmbH Berlin Germany D-1000 , Germany Schering AG, Res Labs, D-1000 Berlin, Germany Schering AG Berlin GermanyD-1000 g AG, Res Labs, D-1000 Berlin, Germany
Titolo Testata:
INVESTIGATIVE RADIOLOGY
fascicolo: 2, volume: 34, anno: 1999,
pagine: 126 - 133
SICI:
0020-9996(199902)34:2<126:GNCT(O>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; CANCER; GROWTH; GD-157;
Keywords:
neutron capture therapy for cancer; gadolinium; MRI contrast agent; melanoma cells; solid tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lawaczeck, R Inst Diagnost Forsch GmbH, Spandauer Damm 130, D-14050 Berlin, Germany Inst Diagnost Forsch GmbH Spandauer Damm 130 Berlin Germany D-14050
Citazione:
B. Hofmann et al., "Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent gadobutrol", INV RADIOL, 34(2), 1999, pp. 126-133

Abstract

RATIONALE AND OBJECTIVES. The therapeutic gain of neutron capture therapy with a neutral macrocyclic gadolinium (Gd) complex (Gadobutrol) was evaluated through in vitro and in vivo studies in a beam of low-energy neutrons. METHODS. Neutron irradiation for both the in vitro and in vivo studies,vasperformed in a beam of low-energy neutrons produced by the research reactor of the Hahn-Meitner-Institut, Berlin. Malignant melanoma cells of human origin were irradiated in the presence or absence of Gadobutrol. In vivo irradiation was performed on tumor-bearing nude mice. The tumor site was irradiated subsequent to intratumoral injection of Gadobutrol and compared with irradiation in the absence of the Gd complex. RESULTS. In vitro studies showed a Gd-dependent delay of cell proliferation as a consequence of neutron irradiation. In animals, intratumoral administration of the Gd complex at a dose of 1.2 mmol Gd/kg before neutron irradiation results in a significant delay in tumor growth with respect to the control groups. CONCLUSIONS. In vitro and in vivo studies showed a therapeutic benefit, with the neutral Gd complex and suggest Gd-containing magnetic resonance contrast media are potential candidates for neutron capture therapy. The Gd dose used in the irradiation experiments was four times the presently acceptedhigh dose in clinical magnetic resonance imaging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:17:37