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Titolo:
The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LID-1(+) NK cell clones
Autore:
Vitale, M; Castriconi, R; Parolini, S; Pende, D; Hsu, ML; Moretta, L; Cosman, D; Moretta, A;
Indirizzi:
Ctr Biotecnol Avanzate, Lab Immunopatol, I-16132 Genoa, Italy Ctr Biotecnol Avanzate Genoa Italy I-16132 nopatol, I-16132 Genoa, Italy Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy Univ Brescia, Dipartimento Sci Biomed & Biotecnol, Brescia, Italy Univ Brescia Brescia Italy mento Sci Biomed & Biotecnol, Brescia, Italy Immunex Res & Dev Corp, Seattle, WA 98101 USA Immunex Res & Dev Corp Seattle WA USA 98101 v Corp, Seattle, WA 98101 USA Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 to Med Sperimentale, I-16132 Genoa, Italy
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 1, volume: 11, anno: 1999,
pagine: 29 - 35
SICI:
0953-8178(199901)11:1<29:TLIR(F>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN NATURAL-KILLER; INHIBITORY RECEPTOR; MOLECULES; RECOGNITION; COMPLEX; CD94; P58; IDENTIFICATION; INVOLVEMENT; EXPRESSION;
Keywords:
cytotoxicity; HLA class I; inhibitory receptors; NK cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Moretta, A Ctroa,otecnol Avanzate, Lab Immunopatol, L Go Rosanna Benzi 10,I-16132 Gen Ctr Biotecnol Avanzate L Go Rosanna Benzi 10 Genoa Italy I-16132
Citazione:
M. Vitale et al., "The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LID-1(+) NK cell clones", INT IMMUNOL, 11(1), 1999, pp. 29-35

Abstract

Leukocyte Ig-like receptor (LIR)-1 is a member of the Ig superfamily whichhas been shown to bind the human cytomegalovirus MHC class I homologue UL-18 protein. In this study, we have analyzed the expression and function of LIR-1 in human NK cells, We show that LIR-1 is expressed by a subset of NK cells variable in size among different donors. When compared to the known HLA class I-specific NK receptors, the expression of LIR-1 was found to be partially overlapped with that of CD94-NKG2A or with that of killer inhibitory receptors (KIR) belonging to the Ig superfamily. The use of the soluble form of UL-18 molecule revealed, in double fluorescence analysis, a selective binding to LIR-1(+) cells while no correlation was observed between expression of either KIR or CD94-NKG2A molecules and ability to bind UL18. We further determined whether LIR-1 could also function as receptor for HLA class I molecules. To this end, we assessed the capability of LIR-1(+) NK cellclones of lysing HLA class I- target cells transfected with different class I alleles, including HLA-A, -B, -C and -G alleles, Data revealed that LIR-1 functions as a broad HLA class I-specific inhibitory receptor recognizing different alleles coded for by different HLA loci.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:54:16