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Titolo:
Molecular characterization of U937-dependent T-cell co-stimulation
Autore:
Stonehouse, TJ; Woodhead, VE; Herridge, PS; Ashrafian, H; George, M; Chain, BM; Katz, DR;
Indirizzi:
Univandll London, Windeyer Inst Med Sci, Dept Immunol, London W1P 6DB, Engl Univ Coll London London England W1P 6DB pt Immunol, London W1P 6DB, Engl
Titolo Testata:
IMMUNOLOGY
fascicolo: 1, volume: 96, anno: 1999,
pagine: 35 - 47
SICI:
0019-2805(199901)96:1<35:MCOUTC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; BLOOD-BRAIN-BARRIER; COSTIMULATORY SIGNAL; SURFACE-PROTEINS; ANTIGEN RECEPTOR; ACTIVATION; CD28; ASSOCIATION; PROLIFERATION; PHOSPHATASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, DR Univdonll London, Windeyer Inst Med Sci, Dept Immunol, 46 Cleveland St, Lon Univ Coll London 46 Cleveland St London England W1P 6DB St, Lon
Citazione:
T.J. Stonehouse et al., "Molecular characterization of U937-dependent T-cell co-stimulation", IMMUNOLOGY, 96(1), 1999, pp. 35-47

Abstract

U937 cells provide a co-stimulatory signal for CD3-mediated T-cell activation which is independent of the CD28/CD80/CD86 interaction. This study set out to identify which molecules contribute to this co-stimulatory activity. Monoclonal antibodies (mAb) to the known accessory molecules CD11a, CD18, CD54 and CD45, all inhibited T-cell proliferation. Although CD11a/18 mAb inhibited U937/T-cell cluster formation as well as proliferation, CD45 enhanced the size of the clusters formed, suggesting that this was not the only mechanism of inhibition. The alternative co-stimulatory pathway provided by U937 cells preferentially stimulated a response in the CD18(+) T-cell population, and this reflected the reduced sensitivity of CD8(+) T cells to CD28-mediated activation. Monoclonal antibodies to three molecules, CD53, CD98 and CD147, also inhibited U937-dependent T-cell proliferation. The mAb to CD98 and CD147 were inhibitory when prepulsed on to the U937 cells, suggesting an effect mediated by these molecules on the antigen-presenting cell.

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Documento generato il 01/12/20 alle ore 08:21:02