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Titolo:
Mechanisms of FK 506-induced hypertension in the rat
Autore:
Takeda, Y; Miyamori, I; Furukawa, K; Inaba, S; Mabuchi, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Hlth Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Fukui Med Sch, Dept Internal Med 3, Fukui 91011, Japan Fukui Med Sch Fukui Japan 91011 Dept Internal Med 3, Fukui 91011, Japan
Titolo Testata:
HYPERTENSION
fascicolo: 1, volume: 33, anno: 1999,
pagine: 130 - 136
SICI:
0194-911X(199901)33:1<130:MOF5HI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CYCLOSPORINE-INDUCED HYPERTENSION; SMOOTH-MUSCLE CELLS; RECEPTOR ANTAGONIST; MESENTERIC-ARTERIES; IN-VIVO; LIVER-TRANSPLANTATION; ENDOTHELIN-1 RELEASE; NATRIURETIC-PEPTIDE; ANGIOTENSIN-II;
Keywords:
FK 506; endothelin receptor antagonist; endothelin; nitric oxide; hypertension; endothelin-converting enzyme; natriuretic peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y KanazawashikawaSch Med, Dept Internal Med 2, 13-1 Takara Machi, Kanazawa, I Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 920 a, I
Citazione:
Y. Takeda et al., "Mechanisms of FK 506-induced hypertension in the rat", HYPERTENSIO, 33(1), 1999, pp. 130-136

Abstract

Tacrolimus (FK 506) is a powerful, widely used immunosuppressant. The clinical utility of FK 506 is complicated by substantial hypertension and nephrotoxicity. To clarify the mechanisms of FK 506-induced hypertension, we studied the chronic effects of FK 506 on the synthesis of endothelin-l (ET-1),the expression of mRNA of ET-I and endothelin-converting enzyme-1 (ECE-1),the endothelial nitric oxide synthase (eNOS) activity, and the expression of mRNA of eNOS and C-type natriuretic peptide (CNP) in rat brood vessels. In addition, the effect of the specific endothelin type A receptor antagonist FR 139317 on FK 506-induced hypertension in mts was studied. FK 506, 5 mg.kg(-1).d(-1) given for 4 weeks, elevated blood pressure from 102+/-13 to 152+/-15 mm Hg and increased the synthesis of ET-1 and the levels of ET-1 mRNA in the mesenteric artery (240% and 230%, respectively). Little change was observed in the expression of ECE-1 mRNA and CNP mRNA. FK 506 decreased eNOS activity and the levels of eNOS mRNA in the aorta (48% and 55%, respectively). The administration of FR 139317 (10 mg.kg(-1).d(-1)) prevented FK 506-induced hypertension in rats. These results indicate that FK 506 may increase blood pressure not only by increasing ET-1 production but also by decreasing NO synthesis in the vasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:38:17