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Titolo:
Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases
Autore:
Muller, A; Gunther, D; Dux, F; Naumann, M; Meyer, TF; Rudel, T;
Indirizzi:
Max Planck Inst Infekt Biol, Mol Biol Abt, D-10117 Berlin, Germany Max Planck Inst Infekt Biol Berlin Germany D-10117 10117 Berlin, Germany
Titolo Testata:
EMBO JOURNAL
fascicolo: 2, volume: 18, anno: 1999,
pagine: 339 - 352
SICI:
0261-4189(19990115)18:2<339:NP(CRC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; HUMAN EPITHELIAL-CELLS; MEMBRANE PROTEIN; LISTERIA-MONOCYTOGENES; MACROPHAGE APOPTOSIS; INFECTED MACROPHAGES; SHIGELLA-FLEXNERI; ORGAN-CULTURE; CYTOCHROME-C; DEATH;
Keywords:
apoptosis; calcium; caspase; endosymbiosis; Neisseria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, TF Maxermanyk Inst Infekt Biol, Mol Biol Abt, Monbijoustr 2, D-10117 Berlin, G Max Planck Inst Infekt Biol Monbijoustr 2 Berlin Germany D-10117
Citazione:
A. Muller et al., "Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases", EMBO J, 18(2), 1999, pp. 339-352

Abstract

The porin (PorB) of Neisseria gonorrhoeae is an intriguing bacterial factor owing to its ability to translocate from the outer bacterial membrane into host cell membranes where it modulates the infection process. Here we report on the induction of programmed cell death after prolonged infection of epithelial cells with pathogenic Neisseria species. The underlying mechanism we propose includes translocation of the porin, a transient increase in cytosolic Ca2+ and subsequent activation of the Ca2+ dependent protease calpain as well as proteases of the caspase family. Blocking the porin channel by ATP eliminates the Ca2+ signal and also abolishes its pro-apoptotic function. The neisserial porins share structural and functional homologies withthe mitochondrial voltage-dependent anion channels (VDAC). The neisserial porin may be an analogue or precursor of the ancient permeability transition pore, the putative central regulator of apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:19:05