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Titolo:
Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less
Autore:
Wu, J; Cohen, SM;
Indirizzi:
European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany
Titolo Testata:
DEVELOPMENT
fascicolo: 1, volume: 126, anno: 1999,
pagine: 109 - 117
SICI:
0950-1991(199901)126:1<109:PAFITD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING SPECIFICITY; LIMB DEVELOPMENT; HOMEODOMAIN PROTEIN; PATTERN-FORMATION; WINGLESS PROTEIN; IMAGINAL DISKS; GENE ACTIVITY; EXTRADENTICLE; EXPRESSION; ENCODES;
Keywords:
Drosophila; Homothorax; Distal-less; proximodistal axis; leg;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, SM European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, Germany European Mol Biol Lab Meyerhofstr 1 Heidelberg Germany D-69117
Citazione:
J. Wu e S.M. Cohen, "Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less", DEVELOPMENT, 126(1), 1999, pp. 109-117

Abstract

The developing legs of Drosophila are subdivided into proximal and distal domains by the activity of the homeodomain proteins Homothorax (Hth) and Distal-less (Dll). The expression domains of Dll and Hth are initially reciprocal. Wingless and Dpp define both domains by activating Dll and by repressing Hth in the distal region of the disc. Wg and Dpp do not act through Dllto repress Hth. Hth functions to reduce the sensitivity of proximal cells to Wg and Dpp. This serves to limit the effective range of these signals inregulating later-acting genes such as Dac. We present evidence that proximal and distal cells tend to sort-out from one another. Cells forced to express Hth are unable to mix with distal cells. Likewise, cells forced to express Dll are unable to mix with proximal cells, Clones of cells unable to express Dll in the distal region sort-out from the disc. Clones of cells unable to express Hth lose the specialized population of cells at the interfacebetween proximal and distal territories and cause fusion between body walland leg segments. These observations suggest that sorting-out behavior of Hth- and Dll-expressing cells contributes to subdivision of the leg into proximal and distal domains.

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Documento generato il 28/11/20 alle ore 20:36:27