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Titolo:
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C-elegans
Autore:
Tabara, H; Hill, RJ; Mello, CC; Priess, JR; Kohara, Y;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Japanokai & Technol Corp, Grad Univ Adv Studies, Dept Genet, Mishima, Shizu Japan Sci & Technol Corp Mishima Shizuoka Japan 411 Genet, Mishima, Shizu JapantSci & Technol Corp, Gene Network Lab, Natl Inst Genet, Core Res Evolu Japan Sci & Technol Corp Mishima Shizuoka Japan 411 Genet, Core Res Evolu Univ Massachusetts, Ctr Canc, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 r Canc, Worcester, MA 01605 USA Univ Washington, Dept Zool, Seattle, WA 98195 USA Univ Washington SeattleWA USA 98195 on, Dept Zool, Seattle, WA 98195 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 1, volume: 126, anno: 1999,
pagine: 1 - 11
SICI:
0950-1991(199901)126:1<1:PEACZP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; NEMATODE CAENORHABDITIS-ELEGANS; MESSENGER-RNA; CELLULAR INTERACTIONS; EMBRYOS; LINEAGE; LOCALIZATION; BLASTOMERE; CLEAVAGE; SEQUENCE;
Keywords:
germ cells; CCCH finger; embryogenesis; Caenorhabditis elegans; POS-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Priess, JR Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 WA 98109 USA
Citazione:
H. Tabara et al., "pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C-elegans", DEVELOPMENT, 126(1), 1999, pp. 1-11

Abstract

Germ cells arise during early C. elegans embryogenesis from an invariant sequence of asymmetric divisions that separate germ cell precursors from somatic precursors. We show that maternal-effect lethal mutations in the gene pos-1 cause germ cell precursors to inappropriately adopt somatic cell fates. During early embryogenesis, pos-1 mRNA and POS-1 protein are present predominantly in the germ precursors. POS-1 is a novel protein with two copiesof a CCCH finger motif previously described in the germline proteins PIE-1and MEX-1 in C, elegans, and in the mammalian TIS11/Nup475/TTP protein, However, mutations in pos-1 cause several defects in the development of the germline blastomeres that are distinct from those caused by mutations in pie-1 or mex-1. The earliest defect detected in pos-1 mutants is the failure to express APX-1 protein from maternally provided apx-1 mRNA, suggesting that POS-1 may have an important role in regulating the expression of maternalmRNAs in germline blastomeres.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:08:40