Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor
Autore:
van Es, JH; Kirkpatrick, C; van de Wetering, M; Molenaar, M; Miles, A; Kuipers, J; Destree, O; Peifer, M; Clevers, H;
Indirizzi:
Univ Utrecht Hosp, Dept Immunol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3508 GA GA Utrecht, Netherlands Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Biol, Chapel Hill, NC 27599 USA Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands Netherlands Inst Dev Biol Utrecht Netherlands NL-3584 CT ht, Netherlands
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 2, volume: 9, anno: 1999,
pagine: 105 - 108
SICI:
0960-9822(19990128)9:2<105:IOAAHO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR LEF-1; BETA-CATENIN; DROSOPHILA; ARMADILLO; ACTIVATION; WINGLESS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Clevers, H Univ Utrecht Hosp, Dept Immunol, POB 85500, NL-3508 GA Utrecht,Netherlands Univ Utrecht Hosp POB 85500 Utrecht Netherlands NL-3508 GA nds
Citazione:
J.H. van Es et al., "Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor", CURR BIOL, 9(2), 1999, pp. 105-108

Abstract

The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase3 beta (GSK-3 beta), axin/conductin and beta-catenin. Complex formation induces the rapid degradation of beta-catenin, In colon carcinoma cells, lossof APC leads to the accumulation of beta-catenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1,2]). Here, we report the identification and genomic structure of APC homologues. Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin, Like APC, APC2 regulates the formation of active beta-catenin-Tcf complexes, as demonstrated using transienttranscriptional activation assays in APC(-/-) colon carcinoma cells. HumanAPC2 maps to chromosome 19p13.3. APC and APC2 may therefore have comparable functions in development and cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:18:30