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Titolo:
Effects of age on working memory: an event-related potential study
Autore:
Pelosi, L; Blumhardt, LD;
Indirizzi:
Univ7Nottingham Hosp, Queens Med Ctr, Dept Clin Neurophysiol, Nottingham NG Univ Nottingham Hosp Nottingham England NG7 2UH rophysiol, Nottingham NG UnivEnglandgham Hosp, Queens Med Ctr, Div Clin Neurol, Nottingham NG7 2UH,Univ Nottingham Hosp Nottingham England NG7 2UH rol, Nottingham NG7 2UH,
Titolo Testata:
COGNITIVE BRAIN RESEARCH
fascicolo: 3, volume: 7, anno: 1999,
pagine: 321 - 334
SICI:
0926-6410(199901)7:3<321:EOAOWM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM-MEMORY; EVOKED-POTENTIALS; BRAIN POTENTIALS; AUDITORY-STIMULI; SCANNING TASK; P3 COMPONENT; OLD ADULTS; LATENCY; RETRIEVAL; DEMENTIA;
Keywords:
age; ERPs; working memory; visual; auditory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Pelosi, L Univ7Nottingham Hosp, Queens Med Ctr, Dept Clin Neurophysiol, Nottingham NG Univ Nottingham Hosp Nottingham England NG7 2UH Nottingham NG
Citazione:
L. Pelosi e L.D. Blumhardt, "Effects of age on working memory: an event-related potential study", COGN BRAIN, 7(3), 1999, pp. 321-334

Abstract

The effects of age on behavioural performance and event-related potentialsrecorded during a working memory task using digits presented either acoustically or visually, were studied in 37 healthy subjects with an age range from 19 to 71 years. With increasing age, psychological tests showed a progressive decline in visuo-spatial performance and both auditory and visual reaction times (RT) increased. There were multiple and varying effects of ageon both early and late ERP components. For both auditory and visual responses, increasing age was associated with an increased amplitude of early positive waves (auditory P100 and visual P145) and, in the oldest subjects, significant delays of the major late positive waves. Other changes were modality-specific with a progressive shift of amplitude maxima in the early negative waves of the visual ERPs (from an N190 peak maximal at Pt in the young, to an N270 peak maximal at Cz in the older subjects) and an altered amplitude distribution of late potentials (after the P250 wave) in the auditory responses. The age at which ERP changes occurred varied-significant latencyprolongations and increases in the amplitude of the major frontal positivewaves occurred only in the oldest subjects, whereas a redistribution of late auditory ERPs also occurred in the intermediate age group. There was no interaction between age and increasing memory load, suggesting that there is no specific effect of age on memory scanning in this age range for these levels of task difficulty. Thus, although performance in working memory wasapparently unaffected by age, as judged by behavioural parameters (apart from slowing of the reaction times), ERPs revealed significant changes in both early and late electrical brain processes associated with working memoryas age increases. These changes which were not symptomatically manifest and only revealed by sensitive tests, may represent subtle dysfunction of working memory (or associated processes) which does not prevent the successfulcompletion of our task, compensatory mechanisms (which are essential to successfully complete the task), or a combination of both age-induced dysfunction and compensatory mechanisms. (C) 1999 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 21:30:41