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Titolo:
BEHAVIORAL-ASSESSMENT IN RATS OF THE ANTIPSYCHOTIC POTENTIAL OF THE POTENT DOPAMINE D-2 RECEPTOR ANTAGONIST, (-)ETICLOPRIDE
Autore:
FERRARI F; GIULIANI D;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,DIV PHARMACOL,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
Pharmacological research
fascicolo: 5, volume: 31, anno: 1995,
pagine: 261 - 267
SICI:
1043-6618(1995)31:5<261:BIROTA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED BENZAMIDE; H-3 ETICLOPRIDE; BRAIN; SULPIRIDE; BINDING; STIMULATION; DRUGS;
Keywords:
ETICLOPRIDE; AGGRESSION; STEREOTYPED BEHAVIOR; DA D-2 RECEPTORS; NEUROLEPTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F. Ferrari e D. Giuliani, "BEHAVIORAL-ASSESSMENT IN RATS OF THE ANTIPSYCHOTIC POTENTIAL OF THE POTENT DOPAMINE D-2 RECEPTOR ANTAGONIST, (-)ETICLOPRIDE", Pharmacological research, 31(5), 1995, pp. 261-267

Abstract

The effects of the selective D-2 DA receptor antagonist, (-)eticlopride, a drug belonging to the benzamide class, were investigated on the D-2 DA agonist SND 919- and CQP 201-403-induced stereotyped behaviour and on CQP 201-403-induced shaking, in rats, and on isolation-induced aggression, in mice. (-)Eticlopride was also tested over a wide dose range (5-1200 mu g kg(-1), s.c.) for sedative and cataleptic activity, in rats, For comparison, some experiments were performed with (-)sulpiride (10 and 40 mg kg(-1), s.c. ) The data obtained show that (-)eticlopride differs from (-)sulpiride and potentially modifies animal behaviour, whether spontaneous or induced; moreover, they suggest a potential clinical use for this neuroleptic in the management of psychotic states.

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Documento generato il 17/01/20 alle ore 21:10:43