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Titolo:
Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus
Autore:
Kyaw, Y; Hasegawa, G; Takatsuka, H; Shimada-Hiratsuka, M; Umezu, H; Arakawa, M; Naito, M;
Indirizzi:
Niigata Univ, Sch Med, Dept Pathol 2, Niigata 9518510, Japan Niigata UnivNiigata Japan 9518510 Dept Pathol 2, Niigata 9518510, Japan Niigata Univ, Sch Med, Dept Internal Med 2, Niigata, Japan Niigata Univ Niigata Japan Sch Med, Dept Internal Med 2, Niigata, Japan
Titolo Testata:
ARCHIVES OF HISTOLOGY AND CYTOLOGY
fascicolo: 5, volume: 61, anno: 1998,
pagine: 383 - 393
SICI:
0914-9465(199812)61:5<383:EOMCFS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; INDUCED GRANULOMA-FORMATION; FACTOR-I; CLASS-B; PLACENTAL DEVELOPMENT; APOPTOTIC THYMOCYTES; MONOCLONAL-ANTIBODY; LIGAND-BINDING; GROWTH-FACTOR; HUMAN CSF-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Kyaw, Y Niigataapanv, Sch Med, Dept Pathol 2, Asahimachi Dori 1, Niigata 9518510, J Niigata Univ Asahimachi Dori 1 Niigata Japan 9518510 a 9518510, J
Citazione:
Y. Kyaw et al., "Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus", ARCH HIST C, 61(5), 1998, pp. 383-393

Abstract

During pregnancy, mouse uterine epithelial cells produce and secrete a large amount of macrophage colony-stimulating factor (M-CSF/CSF-1), Macrophages accumulate and proliferate in the undecidualized endometrium of the pregnant uterus. Observations showed that macrophages expressed scavenger receptor class A (type I and type II) and class C (macrosialin). Scavenger receptors appeared to be involved in the removal of apoptotic cells in the degenerated decidual tissue. The expression of class A and class C scavenger receptor mRNAs in the uterus of pregnant mice was elevated but the expression of class B scavenger receptor (CD36) mRNA was similar to that of non-pregnant mice. The expression of various cytokines and chemokines, including M-CSF, monocyte cheomattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1-alpha), was enhanced in the uterus of pregnant mice, suggesting that these molecules regulate macrophage chemotaxis and immunological function in the uterus. These findings imply that the pregnant uterus provides a microenvironment for the recruitment, differentiation, and proliferation of macrophages and the regulation of scavenger receptor and cytokine expression for a successful pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/05/20 alle ore 21:26:07