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Titolo:
INCREASED SERUM TOTAL CREATINE-KINASE AND CREATINE-KINASE ISOENZYME MB AFTER CRYOSURGICAL ABLATION OF THE PROSTATE
Autore:
LONG JP; FALLICK ML; RAND W;
Indirizzi:
TUFTS UNIV,SCH MED BOSTON MA 02111 TUFTS UNIV,NEW ENGLAND MED CTR HOSP BOSTON MA 02111
Titolo Testata:
The Journal of urology
fascicolo: 5, volume: 157, anno: 1997,
pagine: 1723 - 1726
SICI:
0022-5347(1997)157:5<1723:ISTCAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOKINASE ISOENZYMES; MYOCARDIAL-INFARCTION; LACTATE-DEHYDROGENASE; TISSUE; ADENOCARCINOMA; SPECIFICITY; DIAGNOSIS; BB;
Keywords:
PROSTATIC NEOPLASMS; CRYOSURGERY; ISOENZYMES; CREATINE KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Long et al., "INCREASED SERUM TOTAL CREATINE-KINASE AND CREATINE-KINASE ISOENZYME MB AFTER CRYOSURGICAL ABLATION OF THE PROSTATE", The Journal of urology, 157(5), 1997, pp. 1723-1726

Abstract

Purpose: Several reports have documented that the MB isoenzyme of creatine kinase is present in prostatic tissue. However, since it has been shown that lower urinary tract manipulations, including transurethral prostatectomy, do not significantly increase serum creatine kinase isoenzyme MB levels, such elevations, which are found in patients afterprostatic surgery, are believed to be specific for myocardial infarction. We examined whether cryosurgical ablation of the prostate alteredserum creatine kinase or isoenzyme MB levels. Materials and Methods: In 81 consecutive patients undergoing routine cryosurgical ablation ofthe prostate serum levels of creatine kinase and creatine kinase isoenzyme NIB were measured from peripheral blood specimens drawn preoperatively, in the recovery room and at 8 and 24 hours postoperatively. Postoperative electrocardiograms were compared to the preoperative study. Results: In 72 of 81 patients (89%) significant elevations in creatine kinase and creatine kinase isoenzyme MB levels were noted at all time points after cryosurgical ablation of the prostate and appeared to reach a peak at 16 hours postoperatively. The mean increases within the first 8 hours after cryosurgical ablation of the prostate were 1,355units per 1. for creatine kinase and 46.6 ng./ml. for creatine kinaseisoenzyme MB. No patient had any significant changes on the postoperative electrocardiogram. All 9 patients (11%) who did not have significant creatine kinase or creatine kinase isoenzyme MB levels therapy. Conclusions: Cryosurgical ablation of the prostate appears to produce elevations in serum creatine kinase and creatine kinase isoenzyme MB, which are specific to the procedure. Assays for creatine kinase isoenzyme MB are unreliable to render a diagnosis of myocardial infarction after cryosurgical ablation of the prostate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:30:01