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Titolo:
Protein malnutrition: Some aspects of the in vitro adhesion of peritoneal mouse macrophages
Autore:
Borelli, P; Souza, IP; Borojevic, R; Dagli, MLZ; Kang, HC;
Indirizzi:
Univaulo,Paulo, Fac Ciencias Farmaceut, Lab Hematol Expt, BR-05508900 Sao P Univ Sao Paulo Sao Paulo Brazil BR-05508900 BCol Expt, BR-05508900 Sao P Univzild Rio de Janeiro, Inst Ciencias Biomed, BR-21941 Rio De Janeiro, Bra Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21941 o De Janeiro, Bra Univ Sao Paulo, Fac Med Vet & Zootecn, BR-05508 Sao Paulo, Brazil Univ SaoPaulo Sao Paulo Brazil BR-05508 ecn, BR-05508 Sao Paulo, Brazil
Titolo Testata:
ANNALS OF NUTRITION AND METABOLISM
fascicolo: 6, volume: 42, anno: 1998,
pagine: 367 - 373
SICI:
0250-6807(199811/12)42:6<367:PMSAOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALORIE MALNUTRITION; FIBRONECTIN; MICE;
Keywords:
malnutrition; macrophages; fibronectin; cellular adhesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Borelli, P Univstes Paulo, Fac Ciencias Farmaceut, Lab Hematol Expt, Av Prof Lineu Pre Univ Sao Paulo Av Prof Lineu Prestes 580 Sao Paulo Brazil BR-05508900 BC
Citazione:
P. Borelli et al., "Protein malnutrition: Some aspects of the in vitro adhesion of peritoneal mouse macrophages", ANN NUTR M, 42(6), 1998, pp. 367-373

Abstract

Protein calorie malnutrition and disease are frequently associated, Protein malnutrition modifies both the specific and nonspecific resistance of theorganism to infectious agents. The exact mechanisms underlying these findings are not clear. Cellular adhesion is a crucial step in the process of phagocytosis as well as cellular migration. The effect of a low-protein diet on adhesion of macrophages was studied using an experimental murine model, We used malnourished mice that had lost 30% of their initial body weight, We then injected them with a suspension of sodium caseinate and harvested the peritoneal macrophages after 5 days. The cells were then allowed to adhere to cover slips in the presence or absence of 10% fetal calf serum (FCS) in the medium for time periods of 30, 60, 90 and 120 min. Macrophage adhesion to glass slips whose surface had been covered with type I collagen was performed only for 90 min. The expression of fibronectin was studied using animmunohistochemical technique only in the 90-min assay. The results indicate that (1) protein malnutrition impairs the activation potential of macrophages, decreasing their adhesion and expression of fibronectin; (2) when FCS is present in the medium, there is a decrease in the number of adhered cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 08:05:44