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Titolo:
Analytical and biologic variability in measures of hemostasis, fibrinolysis, and inflammation: Assessment and implications for epidemiology
Autore:
Sakkinen, PA; Macy, EM; Callas, PW; Cornell, ES; Hayes, TE; Kuller, LH; Tracy, RP;
Indirizzi:
Univ Vermont, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA Univ Vermont, Dept Biochem, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 pt Biochem, Burlington, VT 05405 USA Univ Vermont, Dept Math & Stat, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ath & Stat, Burlington, VT 05405 USA Maine Med Ctr, Portland, ME 04102 USA Maine Med Ctr Portland ME USA 04102Maine Med Ctr, Portland, ME 04102 USA Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 idemiol, Pittsburgh, PA 15260 USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 3, volume: 149, anno: 1999,
pagine: 261 - 267
SICI:
0002-9262(19990201)149:3<261:AABVIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED IMMUNOSORBENT-ASSAY; PLASMINOGEN-ACTIVATOR INHIBITOR-1; ACUTE CORONARY SYNDROMES; INTRAINDIVIDUAL VARIABILITY; ARTERY DISEASE; FIBRINOGEN; PLASMA; RISK; PATHOGENESIS; MECHANISMS;
Keywords:
cardiovascular disease; hemostasis; variability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tracy, RP Univ Vermont, Lab Clin Biochem Res, 55A S Pk Dr, Colchester, VT 05446 USA Univ Vermont 55A S Pk Dr Colchester VT USA 05446 r, VT 05446 USA
Citazione:
P.A. Sakkinen et al., "Analytical and biologic variability in measures of hemostasis, fibrinolysis, and inflammation: Assessment and implications for epidemiology", AM J EPIDEM, 149(3), 1999, pp. 261-267

Abstract

An increasing number of cardiovascular epidemiologic studies are measuringnon-traditional risk markers of disease, most of which do not have established biovariability characteristics. When biovariability data have been reported, they usually represent a short time period, and, in any case, there is little consensus on how the information should be used. The authors performed a long-term (6-month) repeated measures study on 26 healthy individuals, and, using a nested analysis of variance (ANOVA) approach, report on the analytical (CVA), intraindividual (CVt), and between individual (CVG) variability of 12 procoagulant, fibrinolysis, and inflammation assays, including total cholesterol for comparison. The results suggest acceptable analytical variability (CVA less than or equal to 1/2 CVt) for all assays. However, there was a large range of intraindividual variation as a proportion of total variance (2-78%), and adjusting for intraindividual and between individual variation in bivariate correlations increased the observed correlationby more than 30 percent for three of these assays. Overall, the assays showed a significant increase in intraindividual variation over 6 months (p < 0.05). While these findings suggest that most of these assays have biovariability characteristics similar to cholesterol, there is variation among assays. Some assays may be better suited to epidemiologic studies, and knowledge of an assay's biovariability data may be useful in interpreting simple statistics, and in designing multivariate models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:00:35