Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pramipexole - Preclinical and clinical data
Autore:
Pollentier, S; Brecht, HM;
Indirizzi:
Boehringer Ingelheim Pharma KG, D-55216 Ingelheim, Germany Boehringer Ingelheim Pharma KG Ingelheim Germany D-55216 elheim, Germany
Titolo Testata:
AKTUELLE NEUROLOGIE
, volume: 25, anno: 1998, supplemento:, 4
pagine: S300 - S304
SICI:
0302-4350(199812)25:<S300:P-PACD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Soggetto:
DOPAMINE-RECEPTOR AGONIST; ADVANCED PARKINSONS-DISEASE; DOUBLE-BLIND; D-3; EFFICACY; BINDING; PLACEBO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Brecht, HM Boehringer Ingelheim Pharma KG, D-55216 Ingelheim, Germany Boehringer Ingelheim Pharma KG Ingelheim Germany D-55216 many
Citazione:
S. Pollentier e H.M. Brecht, "Pramipexole - Preclinical and clinical data", AKT NEUROL, 25, 1998, pp. S300-S304

Abstract

A review of clinical and preclinical data is given. Pramipexole is a highly selective dopamine D-2 agonist with full intrinsic activity. Other than established dopamine agonists, pramipexole is not an ergot derivate. Pharmacokinetic aspects include a high bioavailability (> 90%), a low protein binding (<20%) and a terminal half-life of 8-12 hours. Pramipexole is registered in Europe for the treatment of parkinson's disease in combination with levodopa, in US and Canada as monotherapy. In several in vitro and in vivo models pramipexole showed neuroprotective actions on dopaminerge neurons, long-term trials in parkinsonian patients are currently running. In contrast to bromocriptine pramipexole exhibited a faster onset and a sustained effectwith respect to the education of "off" time. In animal experiments pramipexole, possibly due to its preference for D-3 receptors, showed antidepressant and antianhedonic actions, resp., which may be an additional benefit given the high rate of comorbid mood disorders in parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:02:56