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Titolo:
A plant-seed inhibitor of two classes of alpha-amylases: X-ray analysis ofTenebrio molitor larvae alpha-amylase in complex with the bean Phaseolus vulgaris inhibitor
Autore:
Nahoum, V; Farisei, F; Le-Berre-Anton, V; Egloff, MP; Rouge, P; Poerio, E; Payan, F;
Indirizzi:
CNRS, AFMB, IBSM, F-13402 Marseille 20, France CNRS Marseille France 20CNRS, AFMB, IBSM, F-13402 Marseille 20, France Univ Tuscia, Dipartimento Agrobiol & Agrochim, I-01100 Viterbo, Italy UnivTuscia Viterbo Italy I-01100 iol & Agrochim, I-01100 Viterbo, Italy Inst Pharmacol Biol Struct, UPR 9062, F-31077 Toulouse, France Inst Pharmacol Biol Struct Toulouse France F-31077 1077 Toulouse, France
Titolo Testata:
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
, volume: 55, anno: 1999,
parte:, 1
pagine: 360 - 362
SICI:
0907-4449(199901)55:<360:APIOTC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Nahoum, V CNRS, AFMB, IBSM, 31 Chem Joseph Aiguier, F-13402 Marseille 20, France CNRS 31 Chem Joseph Aiguier Marseille France 20 ille 20, France
Citazione:
V. Nahoum et al., "A plant-seed inhibitor of two classes of alpha-amylases: X-ray analysis ofTenebrio molitor larvae alpha-amylase in complex with the bean Phaseolus vulgaris inhibitor", ACT CRYST D, 55, 1999, pp. 360-362

Abstract

The alpha-amylase from Tenebrio molitor larvae (TMA) has been crystallizedin complex with the alpha-amylase inhibitor (alpha-AI) from the bean Phaseolus vulgaris. A molecular-replacement solution of the structure was obtained using the refined pig pancreatic alpha-amylase (PPA) and alpha-AI atomiccoordinates as starting models. The structural analysis showed that although TMA has the typical structure common to alpha-amylases, large deviationsfrom the mammalian alpha-amylase models occur in the loops. Despite these differences in the interacting loops, the bean inhibitor is still able to inhibit both the insect and mammalian alpha-amylase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:13:30