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Titolo:
Unifying characteristics of sites of anesthetic action revealed by combined use of anesthetics and non-anesthetics
Autore:
Xu, Y; Tang, P; Liachenko, S;
Indirizzi:
Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 are Med, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA
Titolo Testata:
TOXICOLOGY LETTERS
, volume: 101, anno: 1998,
pagine: 347 - 352
SICI:
0378-4274(19981123)101:<347:UCOSOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEYER-OVERTON HYPOTHESIS; INHALED ANESTHETICS; GRAMICIDIN CHANNEL; MEMBRANE-PROTEINS; PHOSPHOLIPIDS; RATS;
Keywords:
anesthetics; nonanesthetics; model membranes; gramicidin A; amphiphilic; NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, Y Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 d, Pittsburgh, PA 15260 USA
Citazione:
Y. Xu et al., "Unifying characteristics of sites of anesthetic action revealed by combined use of anesthetics and non-anesthetics", TOX LETT, 101, 1998, pp. 347-352

Abstract

1. The usefulness of nonanesthetics in the study of mechanisms of general anesthesia lies in the possibility to identify the unifying characteristicsof molecular sites that are shared by the anesthetics but not by the structurally similar nonanesthetics. 2. In model membranes, pairs of structurally similar anesthetics and nonanesthetics showed distinctly different submolecular distributions. 3. This difference may be the underlying cause for the different anesthetic and nonanesthetic interaction with gramicidin A, a model transmembrane cation channel. 4. Generalization of our findings suggests that the nature of the sites, whether in lipids or proteins, must be neither extremely hydrophilic nor extremely lipophilic, but amphiphilic. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:08:51