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Titolo:
Increase of striatal dopamine release by cadmium in nursing rats and its prevention by dexamethasone-induced metallothionein
Autore:
Gutierrez-Reyes, EY; Albores, A; Rios, C;
Indirizzi:
Isticocl Neurol Manuel Velasco Suarez, Dept Neuroquim, Mexico City, DF, Mex Ist Nacl Neurol Manuel Velasco Suarez Mexico City DF Mexico ity, DF, Mex IPN,yCINVESTAV, Dept Farmacol & Toxicol, Secc Toxicol Ambiental, Mexico Cit IPN Mexico City DF Mexico 07300 xicol, Secc Toxicol Ambiental, Mexico Cit
Titolo Testata:
TOXICOLOGY
fascicolo: 2-3, volume: 131, anno: 1998,
pagine: 145 - 154
SICI:
0300-483X(19981116)131:2-3<145:IOSDRB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-DEFICIENT DIET; LIPID-PEROXIDATION; BRAIN SYNAPTOSOMES; CELLS; INJECTION; MECHANISM; TURNOVER; NEUROTOXICITY; INDUCTION; EXPOSURE;
Keywords:
cadmium; corpus striatum; dexamethasone; dopamine; developmental toxicity; metallothionein; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Rios, C Ist3877, Neurol Manuel Velasco Suarez, Dept Neuroquim, Ave Insurgentes Sur Ist Nacl Neurol Manuel Velasco Suarez Ave Insurgentes Sur 3877 Mexico City DF Mexico
Citazione:
E.Y. Gutierrez-Reyes et al., "Increase of striatal dopamine release by cadmium in nursing rats and its prevention by dexamethasone-induced metallothionein", TOXICOLOGY, 131(2-3), 1998, pp. 145-154

Abstract

Repeated daily intraperitoneal (i.p.) administrations of cadmium (CdCl2, 1mg/kg per day for 5 days) increased striatal dopamine (DA) release (180% of controls) and turnover (150% of controls) in 13-day-old rats. Cd treatment also increased striatal metallothionein (MT) content (161%), Cd (127%) and lipid peroxidation (LPO, 190%). In addition, Cd treatment decreased striatal tyrosine hydroxylase (TH) activity (- 28%), and such an effect may result from D-2 receptor blockade as a consequence of excessive dopamine release? since sulpiride (a specific D-2 receptor antagonist) administration to Cd-treated rats abolished the effect of Cd on TH. No effect was observed on striatal monoamine oxidase (MAO) activity. Dexamethasone (Dx) treatment increased striatal MT content and caused no effect on either DA release or turnover. However, Dr administration prevented the effects caused by Cd, including the increased DA release and enhanced striatal lipid peroxidation. These results indicate that toxic effects on the brain are to be expected as aresult of Cd exposure and that Dr administration can attenuate them. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:55:27