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Titolo:
C677T MTHFR mutation and factor V Leiden mutation in patients with TIA Minor stroke: A case-control study
Autore:
Lalouschek, W; Aull, S; Serles, W; Schnider, P;
Indirizzi:
Univ Vienna, Neurol Clin, Sch Med, A-1097 Vienna, Austria Univ Vienna Vienna Austria A-1097 Clin, Sch Med, A-1097 Vienna, Austria Univ Vienna, Dept Lab Med, Sch Med, Div Mol Biol, A-1097 Vienna, Austria Univ Vienna Vienna Austria A-1097 , Div Mol Biol, A-1097 Vienna, Austria Univ Vienna, Dept Med 1, Sch Med, Div Hematol & Hemostaseol, A-1097 Vienna, Univ Vienna Vienna Austria A-1097 Hematol & Hemostaseol, A-1097 Vienna,
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 2, volume: 93, anno: 1999,
pagine: 61 - 69
SICI:
0049-3848(19990115)93:2<61:CMMAFV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; METHYLENE TETRAHYDROFOLATE REDUCTASE; ISCHEMIC CEREBROVASCULAR-DISEASE; CORONARY-ARTERY DISEASE; COMMON MUTATION; RISK FACTOR; MYOCARDIAL-INFARCTION; VENOUS THROMBOSIS; VASCULAR-DISEASE;
Keywords:
cerebrovascular disease; MTHFR mutation; factor V Leiden; homocysteine; risk factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lalouschek, W Univustriaa, Neurol Clin, Sch Med, Wahringer Gurtel 18-20, A-1097 Vienna, A Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1097 A
Citazione:
W. Lalouschek et al., "C677T MTHFR mutation and factor V Leiden mutation in patients with TIA Minor stroke: A case-control study", THROMB RES, 93(2), 1999, pp. 61-69

Abstract

A common C677T mutation in the gene for the enzyme 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) has been linked to elevated levels of homocysteine and was therefore suspected to be a candidate genetic risk factor for arterial occlusive disease. Another mutation, factor V Leiden, has been established as a common hereditary risk factor for venous thrombosis, but its role in arterial disease remains controversial. We investigated the prevalence of both the C677T MTHFR mutation and the factor V Leiden mutation in 81 patients with transient ischemic attack (TIA) or minor stroke (MS) and in 81 age- and sex-matched control subjects free from clinically manifest vascular disease. We further compared clinical and laboratory data as well asclinical course of patients carrying the factor V Leiden mutation alone orin combination with the C677T MTHFR mutation and mutation-free patients. The prevalence of the MTHFR mutation did not differ between patients and control subjects with 11.1% homozygous carriers in both groups (OR for homozygous carriers 1.0;95% CI 0.38-2.66). However, there was a trend towards a higher prevalence of carriers of factor V Leiden in patients (12.3%) than in control subjects (4.9%) (OR 2.75; 95% CI 0.83-9.17; p=0.09). Furthermore, we found some evidence that the combined occurrence of the C677T MTHFR mutation and factor V Leiden might unfavorably affect the clinical course of thedisease, but the number of respective patients was small. Larger studies with a greater number of carriers of both the C677T MTHFR mutation and factor V Leiden seem therefore warranted. (C) 1999 Elsevier Science Ltd. All rights reserved.

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Documento generato il 17/09/19 alle ore 23:26:42