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Titolo:
Laminin inhibits Cl--secretion across canine tracheal epithelium
Autore:
Yamamoto, M; Yamaya, M; Shimura, S; Satoh, M; Sasaki, T; Shirato, K;
Indirizzi:
Tohoku Univ, Sch Med, Dept Internal Med 1, Aoba Ku, Sendai, Miyagi 9808574, Tohoku Univ Sendai Miyagi Japan 9808574 Aoba Ku, Sendai, Miyagi 9808574, Tohokupaniv, Sch Med, Dept Geriatr Med, Aoba Ku, Sendai, Miyagi 9808574, Ja Tohoku Univ Sendai Miyagi Japan 9808574 ba Ku, Sendai, Miyagi 9808574, Ja
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 3, volume: 114, anno: 1998,
pagine: 277 - 284
SICI:
0034-5687(199812)114:3<277:LICACT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-DEPENDENT REGULATION; BIOELECTRIC PROPERTIES; CHLORIDE CHANNELS; BASEMENT-MEMBRANE; ION-TRANSPORT; SERUM LAMININ; CELLS; GLYCOPROTEIN; MODULATION; COMPONENTS;
Keywords:
epithelium, tracheal, bioelectric properties; mammals, dog; membrane, epithelium, laminin; protein, laminin; upper airways, tracheal epithelium, laminin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Shirato, K Tohokui,niv, Sch Med, Dept Internal Med 1, Aoba Ku, 1-1 Seiryo Machi, Senda Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Senda
Citazione:
M. Yamamoto et al., "Laminin inhibits Cl--secretion across canine tracheal epithelium", RESP PHYSL, 114(3), 1998, pp. 277-284

Abstract

We examined the effect of laminin (a major component of the basement membrane) on potential difference (PD) and short circuit current (SCC) in both posterior epithelial membranes (native tissue) and cultured epithelial cell layers from canine trachea using an Ussing chamber. Although laminin itselfdid not alter the baseline values of SCC or PD, it significantly inhibitedin a dose-dependent manner the isoproterenol induced SCC and PD rises of the epithelial membrane. In the cultured epithelial layer treated with amiloride, laminin did not alter the baseline values of SCC, PD or resistance (R) but it significantly inhibited the isoproterenol induced SCC rises. However, laminin did not significantly inhibit the bradykinin induced SCC rise in the cultured epithelial layer treated with amiloride. These findings indicate that laminin is a determinant in ion transport (mainly Cl- secretion) across canine tracheal epithelium, inhibiting the beta-agonist induced Cl- transport. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:18:59