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Titolo:
CINGULATE FUNCTION IN DEPRESSION - A POTENTIAL PREDICTOR OF TREATMENTRESPONSE
Autore:
MAYBERG HS; BRANNAN SK; MAHURIN RK; JERABEK PA; BRICKMAN JS; TEKELL JL; SILVA JA; MCGINNIS S; GLASS TG; MARTIN CC; FOX PT;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,RES IMAGING CTR,7703 FLOYD CURL DR SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PSYCHIAT SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT NEUROL SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT RADIOL SAN ANTONIO TX 78284
Titolo Testata:
NeuroReport
fascicolo: 4, volume: 8, anno: 1997,
pagine: 1057 - 1061
SICI:
0959-4965(1997)8:4<1057:CFID-A>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; PREFRONTAL CORTEX; SUICIDE VICTIMS; BRAIN; MONKEY; CYTOARCHITECTURE; METABOLISM;
Keywords:
CINGULATE; DEPRESSION; LIMBIC; METABOLISM; PET; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Mayberg et al., "CINGULATE FUNCTION IN DEPRESSION - A POTENTIAL PREDICTOR OF TREATMENTRESPONSE", NeuroReport, 8(4), 1997, pp. 1057-1061

Abstract

THE relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolardepression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolismcharacterized non-responders when compared with controls, in contrastto responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinicalor behavioral measures, including motor speed, cognitive performance,depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failureof this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:00:43