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Titolo:
Behavior and drug measurements in Long-Evans and Sprague-Dawley rats afterethanol-cocaine exposure
Autore:
Horowitz, JM; Bhatti, E; Devi, BG; Torres, G;
Indirizzi:
SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 Neurosci Program, Buffalo, NY 14260 USA Res Inst Addict, Off Alcohol & Subst Abuse Serv, Buffalo, NY 14203 USA ResInst Addict Buffalo NY USA 14203 st Abuse Serv, Buffalo, NY 14203 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 62, anno: 1999,
pagine: 329 - 337
SICI:
0091-3057(199902)62:2<329:BADMIL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOS-LIKE PROTEIN; ALCOHOL-CONSUMPTION; COCAETHYLENE; LEWIS; PHARMACOKINETICS; SENSITIZATION; FISCHER-344; METABOLISM; CONCURRENT; MECHANISMS;
Keywords:
cocaethylene; genotype; blood; liver; striatum; catalase; esterase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Torres, G SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 rogram, Buffalo, NY 14260 USA
Citazione:
J.M. Horowitz et al., "Behavior and drug measurements in Long-Evans and Sprague-Dawley rats afterethanol-cocaine exposure", PHARM BIO B, 62(2), 1999, pp. 329-337

Abstract

Long-Evans and Sprague-Dawley rats show differential behavioral responses to cocaethylene, a metabolite derived from the simultaneous ingestion of ethanol and cocaine. Such differences may also be manifested when these outbred strains are exposed to ethanol and cocaine. To test this hypothesis, both strains were fed an ethanol-diet (8.7% v/v) in conjunction with cocaine (15 mg/kg) injections for 15 days. The following parameters were evaluated: (a) ethanol consumption, (b) cocaine-induced behavioral activity, (c) bloodethanol levels, (d) blood, liver, or brain cocaine and cocaethylene levels, and (e) liver catalase and esterase activity. We found that Long-Evans rats drank significantly more of the ethanol diet relative to the Sprague-Dawley line during the first few days of the test session. This rat phenotype also differed significantly from the Sprague-Dawley line in terms of behavioral activity after cocaine administration. Blood ethanol levels did not differ between strains. Similarly, we failed to detect strain-dependent differences in blood, liver, or brain cocaine levels as measured by gas chromatography/mass spectrometry. Cocaethylene levels, however, were higher in blood and brain of Long-Evans relative to Sprague-Dawley cohorts. Although the ethanol-cocaine regimen produced a marked suppression of catalase and esterase activity compared with control-fed rats, this suppression was roughly equivalent in both rat phenotypes. These data are discussed in the context of genotypic background and vulnerability to polysubstance abuse. (C) 1999 Elsevier Science Inc.

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Documento generato il 26/09/20 alle ore 05:44:31