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Titolo:
Penetration studies of clotrimazole from semisolid formulation using step-scan FT-IR photoacoustic spectroscopy
Autore:
Schendzielorz, A; Hanh, BD; Neubert, RHH; Wartewig, S;
Indirizzi:
UnivHalle, Wittenberg, Sch Pharm, Inst Pharmaceut & Biopharmaceut, D-06120Univ Halle Wittenberg Halle Germany D-06120 eut & Biopharmaceut, D-06120 Inst Appl Dermatopharm, Halle, Germany Inst Appl Dermatopharm Halle Germany Appl Dermatopharm, Halle, Germany
Titolo Testata:
PHARMACEUTICAL RESEARCH
fascicolo: 1, volume: 16, anno: 1999,
pagine: 42 - 45
SICI:
0724-8741(199901)16:1<42:PSOCFS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRADITIONAL DIFFUSION CELLS; MULTILAYER MEMBRANE SYSTEM; SYNTHETIC MEMBRANES; PERMEABILITY DATA; DRUG PENETRATION; HUMAN SKIN; TRANSPORT;
Keywords:
penetration; step-scan FT-IR photoacoustic spectroscopy; multilayer membrane; diffusion coefficient; clotrimazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Neubert, RHH Univ Halle Wittenberg, Sch Pharm, Inst Pharmaceut & Biopharmaceut, Wolfgang Univ Halle Wittenberg Wolfgang Langenbeck Str 4 Halle Germany D-06120
Citazione:
A. Schendzielorz et al., "Penetration studies of clotrimazole from semisolid formulation using step-scan FT-IR photoacoustic spectroscopy", PHARM RES, 16(1), 1999, pp. 42-45

Abstract

Purpose. The aim of this study was to elucidate the potential use of the step-scan FT-IR photoacoustic spectroscopy (PAS) for the nondestructive determination of drug penetration into membranes. Methods. The penetration of clotrimazole from a 10% (w/w) suspension in Vaseline(R) into a dodecanol-collodion acceptor membrane was studied by threemethods: the step-scan FT-IR PAS with a phase modulation, a multilayer membrane system, and a modified libration model. Based on Fick's second law, the diffusion coefficient of the drug in the membrane was derived by numerical fitting of the experimental data. Results. The three methods applied provided almost the same diffusion coefficient D = 2.2 10(-9) cm(2)/s for clotrimazole in the membrane. Because ofthe non-destructive mode of operation, the accuracy of results obtained byFT-IR PAS is much better than that attainable by other two methods. Conclusions. Step-scan FT-IR photoacoustic spectroscopy in conjunction with a phase modulation is useful to determine the penetration of drug throughmembranes. The fact that samples can be investigated without elaborate preparation is an advantage of this spectroscopic technique.

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Documento generato il 14/07/20 alle ore 03:35:32