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Titolo:
Serial electroencephalographic findings in patients with MELAS
Autore:
Fujimoto, S; Mizuno, K; Shibata, H; Kanayama, M; Kobayashi, M; Sugiyama, N; Ban, K; Ishikawa, T; Itoh, T; Togari, H; Wada, Y;
Indirizzi:
NagoyaJapan Univ, Sch Med, Dept Lab Med, Mizuho Ku, Nagoya, Aichi 4678601,Nagoya City Univ Nagoya Aichi Japan 4678601 ho Ku, Nagoya, Aichi 4678601, Nagoyaapany Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, J Nagoya City Univ Nagoya Aichi Japan 4678601 Ku, Nagoya, Aichi 4678601, J Nagoya City Univ Hosp, Dept Cent Clin Labs, Nagoya, Aichi, Japan Nagoya City Univ Hosp Nagoya Aichi Japan Clin Labs, Nagoya, Aichi, Japan Midori Municipal Hosp, Dept Pediat, Nagoya, Aichi, Japan Midori Municipal Hosp Nagoya Aichi Japan pt Pediat, Nagoya, Aichi, Japan
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 1, volume: 20, anno: 1999,
pagine: 43 - 48
SICI:
0887-8994(199901)20:1<43:SEFIPW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL MYOPATHY; LACTIC-ACIDOSIS; EPISODES MELAS; STROKELIKE EPISODES; CLINICAL-FEATURES; ENCEPHALOPATHY; ENCEPHALOMYOPATHY; DEFICIENCY; MUTATION; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimoto, S NagoyaJapan Univ, Sch Med, Dept Lab Med, Mizuho Ku, Nagoya, Aichi 4678601, Nagoya City Univ Nagoya Aichi Japan 4678601 a, Aichi 4678601,
Citazione:
S. Fujimoto et al., "Serial electroencephalographic findings in patients with MELAS", PED NEUROL, 20(1), 1999, pp. 43-48

Abstract

To clarify the electroencephalographic characteristics of mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS), the medical records and electroencephalograms of six patients with MELAS andtwo of their relatives with MELA (mitochondrial myopathy, encephalopathy, and lactic acidosis, without strokelike episodes) were retrospectively reviewed. All have a point mutation in the mitochondrial DNA at nucleotide position 3243, The electroencephalograms (n = 79) were divided into four groupsaccording to the time relation to the strokelike episode: (1) before the first strokelike episode, (2) within 5 days after the strokelike episode (acute stage), (3) between 6 days and 1 month after the strokelike episode (subacute stage), and (4) more than 1 month after the strokelike episode (chronic stage). In the acute stage, 10 of the 11 electroencephalograms (9 strokelike episodes in four patients) revealed focal high-voltage delta waves with polyspikes (FHDPS), which were recognized as ictal electroencephalogram. Ictal events during FHDPS included focal clonic or myoclonic seizure and migrainous headache. In the subacute and chronic stages, focal spikes or sharp waves and 14- and 6-Hz positive bursts were frequently recorded, The authors' results suggest that FHDPSs present a reliable and accurate indicatorof a strokelike episode in patients with MELAS. (C) 1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:42:52