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Titolo:
SPATIAL MEMORY IN TRANSGENIC MICE WITH IMPAIRED GLUCOCORTICOID RECEPTOR FUNCTION
Autore:
ROUSSE I; BEAULIEU S; ROWE W; MEANEY MJ; BARDEN N; ROCHFORD J;
Indirizzi:
MCGILL UNIV,DEPT PSYCHIAT,DOUGLAS HOSP,RES CTR,6875 LA SALLE BLVD VERDUN PQ H4H 1RS CANADA MCGILL UNIV,DEPT PSYCHIAT,DOUGLAS HOSP,RES CTR VERDUN PQ H4H 1RS CANADA NIMH,BIOL PSYCHIAT BRANCH BETHESDA MD 20892 UNIV LAVAL,DEPT PHYSIOL QUEBEC CITY PQ CANADA
Titolo Testata:
NeuroReport
fascicolo: 4, volume: 8, anno: 1997,
pagine: 841 - 845
SICI:
0959-4965(1997)8:4<841:SMITMW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE-AGED RATS; ANTISENSE RNA; YOUNG; DEFICITS;
Keywords:
GLUCOCORTICOID RECEPTORS; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; MICE; MORRIS WATER MAZE; RADIAL ARM MAZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
I. Rousse et al., "SPATIAL MEMORY IN TRANSGENIC MICE WITH IMPAIRED GLUCOCORTICOID RECEPTOR FUNCTION", NeuroReport, 8(4), 1997, pp. 841-845

Abstract

SPATIAL learning and memory function of transgenic mice with impairedglucocorticoid receptor function was assessed in the Morris water maze and the radial arm maze. Transgenic mice took longer to find a submerged and a visual platform in the water maze task than did mice from the parent strain (B6C/3F1), although performance was improved in the visible platform condition relative to the submerged platform task. In the radial arm maze, transgenic mice made significantly more errors than B6C/3F1 mice. In both tasks, the behavioural strategies adopted by transgenic mice were non-optimal for correct performance. It is suggested that the impaired performance displayed by transgenic mice in bothtests is largely attributable to these altered behavioural strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:17:28