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Titolo:
EFFECTS OF DEOXYCORTICOSTERONE ACETATE AND DIAZEPAM ON NEUROPEPTIDERGIC NEURONS IN RAT STRIATUM
Autore:
LUCAS LR; POMPEI P; MCEWEN BS;
Indirizzi:
ROCKEFELLER UNIV,NEUROENDOCRINOL LAB,1230 YORK AVE,BOX 165 NEW YORK NY 10021 UNIV CAMERINO,INST PHARMACOL I-62032 CAMERINO ITALY
Titolo Testata:
NeuroReport
fascicolo: 4, volume: 8, anno: 1997,
pagine: 811 - 816
SICI:
0959-4965(1997)8:4<811:EODAAD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-LIKE IMMUNOREACTIVITY; GLUCOCORTICOID REGULATION; INSITU HYBRIDIZATION; GENE-EXPRESSION; GABA RECEPTOR; MESSENGER-RNA; SUBSTANCE-P; SALT INTAKE; BRAIN; ENKEPHALIN;
Keywords:
BENZODIAZEPINES; DOPAMINE; DYNORPHIN; ENKEPHALIN; GABA; NEUROPEPTIDES; NEUROSTEROIDS; NUCLEIC ACID HYBRIDIZATION; SUBSTANCE P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L.R. Lucas et al., "EFFECTS OF DEOXYCORTICOSTERONE ACETATE AND DIAZEPAM ON NEUROPEPTIDERGIC NEURONS IN RAT STRIATUM", NeuroReport, 8(4), 1997, pp. 811-816

Abstract

THE neurosteroid tetrahydrodeoxycorticosterone (THDOC) interacts withgamma-aminobutyric acid (GABA)/ benzodiazepine (BZ) receptors. To test the hypothesis that THDOC works partially through mechanisms associated with GABA(A)/BZ receptor function, deoxycorticosterone acetate (DOCA) and the benzodiazepine, diazepam (DZ), were administered short- (1day) and long-term (11 days). Levels of mRNA for dynorphin, preprotachykinin and preproenkephalin in the striatum of adult male Sprague-Dawley rats were measured by in situ hybridization. Acute DOCA and DZ treatment produced parallel neuropeptide mRNA profiles, whereas chronic DOCA and DZ treatment yielded different patterns of neuropeptide gene expression. Chronic DZ treatment resulted in no significant increase insalt intake whereas chronic DOCA activated salt appetite. We suggest that acute DZ and DOCA interact with GABA(A)/BZ receptors; however, the results of chronic treatment suggest that DZ and DOCA operate through dissimilar mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:51:23