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Titolo:
Local infusion of the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione does not block D-1 dopamine receptor-mediated increases in immediate early gene expression in the dopamine-depleted striatum
Autore:
Keefe, KA; Gerfen, CR;
Indirizzi:
NIMH, Lab Syst Neurosci, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 IMH, Lab Syst Neurosci, Bethesda, MD 20892 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 89, anno: 1999,
pagine: 491 - 504
SICI:
0306-4522(199903)89:2<491:LIOT(>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPRODYNORPHIN MESSENGER-RNA; EXCITATORY AMINO-ACIDS; C-FOS INDUCTION; RAT STRIATUM; EXTRACELLULAR DOPAMINE; NEURONS INVITRO; NMDA RECEPTORS; PHENOTYPICAL CHARACTERIZATION; CORTICOSTRIATAL AFFERENTS; INVIVO MICRODIALYSIS;
Keywords:
glutamate; c-fos; zif268; SKF 38393; in situ hybridization; tetrodotoxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Gerfen, CR NIMH, Lab Syst Neurosci, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 st Neurosci, Bethesda, MD 20892 USA
Citazione:
K.A. Keefe e C.R. Gerfen, "Local infusion of the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione does not block D-1 dopamine receptor-mediated increases in immediate early gene expression in the dopamine-depleted striatum", NEUROSCIENC, 89(2), 1999, pp. 491-504

Abstract

Administration of selective agonists of D-1 dopamine receptors increases immediate early gene expression in striatal neurons, a response which is particularly robust in the dopamine-depleted striatum. Although interactions between dopamine and glutamate receptor-mediated responses in striatal neurons have been demonstrated in a number of experimental paradigms, our previous findings indicate that N-methyl-D-aspartate antagonists do not block D-1receptor-mediated induction of immediate early genes in the dopamine-depleted striatum. In the present study, we therefore examined interactions between D-1 dopamine receptors and the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole- subtypes of glutamate receptor by determining whether striatal infusion of the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole(-)4(-)propionate/kainate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione would block D, receptor-mediated induction of the immediate early genes c-fos and zif268 in thedopamine-depleted striatum. Striatal infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (1 mM) completely blocked (+/-)alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate-induced c-Sos and zif268 expression. However, 6-cyano-7-nitroquinoxaline-2,3-dione (1 mu M-1 mM) did not significantly affect induction of c-Sos and zif268 by D-1 receptor stimulation (SKF 38393, 2 mg/kg,i.p.) in the dopamine-depleted striatum. To more generally block excitatory input, tetrodotoxin (10 mu M) was infused into the striatum of rats receiving a D-1 agonist. Local infusion of tetrodotoxin had minimal effect on induction of c-fos and zif268 in the dopamine-depleted striatum. In contrast,tetrodotoxin abolished induction of c-fos and zif268 messenger RNAs by theD-2 antagonist eticlopride (0.5 mg/kg, i.p.) in both intact rats and dopamine-depleted rats receiving continuous D-2 agonist treatment (quinpirole, 0.5 mg/kg/day). The results indicate that D-1 receptor-mediated induction of immediate early genes in the dopamine-depleted striatum occurs by mechanisms that are independent of excitatory input through (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors.

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Documento generato il 07/04/20 alle ore 03:05:31