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Titolo:
Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor
Autore:
Tzeng, SF; Deibler, GE; DeVries, GH;
Indirizzi:
Edward Hines Vet Adm Hosp, Res Serv, Res 151, Hines, IL 60141 USA Edward Hines Vet Adm Hosp Hines IL USA 60141 Res 151, Hines, IL 60141 USA Loyola60153, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, Maywood, ILLoyola Univ Maywood IL USA 60153 Cell Biol Neurobiol & Anat, Maywood, IL NIMH, Cerebral Metab Lab, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 erebral Metab Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 2, volume: 24, anno: 1999,
pagine: 255 - 260
SICI:
0364-3190(199902)24:2<255:MBPAMB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTORS; NERVE;
Keywords:
myelin basic protein; mitogens; Schwann cell; ganglioside;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: DeVries, GH Edward,Hines Vet Adm Hosp, Res Serv, Res 151, 5th Ave & Roosevelt Rd, Hines Edward Hines Vet Adm Hosp 5th Ave & Roosevelt Rd Hines IL USA60141
Citazione:
S.F. Tzeng et al., "Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor", NEUROCHEM R, 24(2), 1999, pp. 255-260

Abstract

Myelin basic protein (MBP) and two peptides derived from MBP (MBP1-44 and MBP152-167) stimulated Schwann cell (SC) proliferation in a cAMP-mediated process. The two mitogenic regions of MBP did not compete with one another for binding to SC suggesting a distinctive SC receptor for each mitogenic peptide. Neutralizing antibodies to the fibroblast growth factor receptor blocked the mitogenic effect of the myelin-related SC mitogen found in the supernatant of myelin-fed macrophages. The binding of I-125-MBP to Schwann cells was specifically inhibited by basic fibroblast growth factor (bFGF) and conversely the binding of I-125-bFGF was competitively inhibited by MBP. These data suggested that the mitogenic effect of one MBP peptide was mediated by a bFGF receptor. The binding of MBP to ganglioside GM1 and the abilityof MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1 ) to compete for the binding of a mitogenic peptide (MBP1-44) to SC, identified ganglioside GM1 as a second SC receptor. Based on these results, we conclude that MBP1-44 and MBP152-167 associate with ganglioside GM1 and the bFGF receptor respectively to stimulate SC mitosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:18:44