Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HEPATOBILIARY AND PANCREATIC MUCINOUS CYSTADENOCARCINOMAS WITH MESENCHYMAL STROMA - ANALYSIS OF ESTROGEN-RECEPTORS PROGESTERONE RECEPTORS AND EXPRESSION OF TUMOR-ASSOCIATED ANTIGENS
Autore:
WEIHING RR; SHINTAKU IP; GELLER SA; PETROVIC LM;
Indirizzi:
CEDARS SINAI MED CTR,DEPT PATHOL & LAB MED,8700 BEVERLY BLVD LOS ANGELES CA 90048 CEDARS SINAI MED CTR,DEPT PATHOL & LAB MED LOS ANGELES CA 90048
Titolo Testata:
Modern pathology
fascicolo: 4, volume: 10, anno: 1997,
pagine: 372 - 379
SICI:
0893-3952(1997)10:4<372:HAPMCW>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; MONOCLONAL-ANTIBODIES; CYSTIC NEOPLASMS; HUMAN-LIVER; IMMUNOHISTOCHEMICAL DETECTION; PRECURSOR LESIONS; GALL-BLADDER; P53 PROTEIN; CYSTADENOMA; TISSUES;
Keywords:
BCL-2; C-ERBB-2; ESTROGEN RECEPTOR; MESENCHYMAL STROMA; MUCINOUS CYSTADENOCARCINOMA; P53; PROGESTERONE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Weihing et al., "HEPATOBILIARY AND PANCREATIC MUCINOUS CYSTADENOCARCINOMAS WITH MESENCHYMAL STROMA - ANALYSIS OF ESTROGEN-RECEPTORS PROGESTERONE RECEPTORS AND EXPRESSION OF TUMOR-ASSOCIATED ANTIGENS", Modern pathology, 10(4), 1997, pp. 372-379

Abstract

Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma are relatively rare neoplasms that occur preponderantly in women, suggesting a role for unidentified sex-specific factor(s) in the pathogenesis of these tumors, We used paraffin tissue immunohistochemical analysis with an appropriate panel of monoclonal antibodies tolook for estrogen and progesterone receptors in two cases of hepatobiliary mucinous cystadenocarcinoma with mesenchymal stroma and one caseof pancreatic mucinous cystadenocarcinoma In all three of these cases, the nuclei of tumor stroma and, in the hepatic tumors, the nuclei oftumor epithelium, reacted with both antibodies. These data strongly suggest that a relationship to hormonal functions exists for these tumors, Because of the rarity of these tumors we also investigated the expression of a variety of oncoprotein antigens, epithelial antigens, andcytoskeletal antigens, The oncoprotein antigens, p53 and c-erbB-2, were focally expressed in hepatic and pancreatic tumor epithelium; bcl-2was focally expressed in hepatic tumor epithelium. Keratin was strongly expressed in most epithelial cells, In addition, epithelial membrane antigen, carcinoembryonic antigen, and chromogranin were focally expressed in epithelial cells, Actin and vimentin were strongly expressedin most stromal cells but not in epithelial cells, and desmin expression was similar but less widespread.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:48:58