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Titolo:
IS DIFFERENTIAL REGULATION OF MITOCHONDRIAL TRANSCRIPTS IN PARKINSONS-DISEASE RELATED TO APOPTOSIS
Autore:
RUBERG M; BRUGG B; PRIGENT A; HIRSCH E; BRICE A; AGID Y;
Indirizzi:
HOP LA PITIE SALPETRIERE,INSERM,U289,47 BD HOP F-75013 PARIS FRANCE INSERM,U289 PARIS FRANCE
Titolo Testata:
Journal of neurochemistry
fascicolo: 5, volume: 68, anno: 1997,
pagine: 2098 - 2110
SICI:
0022-3042(1997)68:5<2098:IDROMT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ELECTRON-TRANSPORT CHAIN; COMPLEX-I DEFICIENCY; SKELETAL-MUSCLE; MESSENGER-RNA; INSITU HYBRIDIZATION; HUNTINGTONS-DISEASE; CYTOCHROME-OXIDASE; ALZHEIMERS-DISEASE; RESPIRATORY-CHAIN;
Keywords:
PARKINSONS DISEASE; CDNA; LIBRARY; MITOCHONDRIA; APOPTOSIS; DOPAMINERGIC NEURONS; SPHINGOMYELIN SIGNALING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M. Ruberg et al., "IS DIFFERENTIAL REGULATION OF MITOCHONDRIAL TRANSCRIPTS IN PARKINSONS-DISEASE RELATED TO APOPTOSIS", Journal of neurochemistry, 68(5), 1997, pp. 2098-2110

Abstract

A cDNA library of substantia nigra pars compacta from a patient with Parkinson's disease (PD) was differentially screened with probes of normal and parkinsonian substantia nigra enriched in neuronal transcripts. Fifty-eight clones were isolated; 39 were subunits of mitochondrialrespiratory complexes I and IV. Parallel screening of a cDNA library derived from normal substantia nigra confirmed differential representation of the transcripts in the substantia nigra pars compacta. In situhybridization in postmortem brain from parkinsonian and control subjects, with representative complex I and complex IV probes, showed increased labeling, at the cellular level, of the complex I subunit ND1 in neurons of the lateral substantia nigra, where cell death is greatest in PD, but decreased labeling in the medial substantia nigra where fewer cells die. Expression of a complex IV subunit, COXI, increased, however, in both parts of the structure, Increased expression of ND1 and COXI was also observed in nerve growth factor-differentiate PC12 cellsundergoing apoptosis induced by tumor necrosis factor-alpha, suggesting that the differential regulation of certain mitochondrial mRNAs maybe associated with this form of cell death. This in vitro model of apoptosis is potentially relevant to the death of dopaminergic neurons in PD, because these cells express the tumor necrosis factor-alpha receptor, and neighboring microglial cells in patients synthesize the cytokine.

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Documento generato il 01/04/20 alle ore 02:20:54