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Titolo:
Cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis
Autore:
Schneider, A; Harendza, S; Zahner, G; Jocks, T; Wenzel, U; Wolf, G; Thaiss, F; Helmchen, U; Stahl, RAK;
Indirizzi:
Univ Hamburg, Dept Med, Div Nephrol, Hamburg, Germany Univ Hamburg Hamburg Germany g, Dept Med, Div Nephrol, Hamburg, Germany Univ Hamburg, Dept Pathol, Hamburg, Germany Univ Hamburg Hamburg Germany niv Hamburg, Dept Pathol, Hamburg, Germany
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 2, volume: 55, anno: 1999,
pagine: 430 - 441
SICI:
0085-2538(199902)55:2<430:CMMGMC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ANTIBODY-INDUCED GLOMERULONEPHRITIS; HUMAN MESANGIAL CELLS; STIMULATING FACTOR-I; SMOOTH-MUSCLE CELLS; NF-KAPPA-B; FACTOR-ALPHA; EXPRESSION; GENE; ACID;
Keywords:
leukocytes; glomerular injury; inflammation; COX-2; chemokine; monocyte chemoattractant protein-1; enzyme;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Stahl, RAK Univ20246kenhaus Eppendorf, Med Klin, Abt Nephrol Osteol, Martinistr 52, D- Univ Krankenhaus Eppendorf Martinistr 52 Hamburg Germany D-20246
Citazione:
A. Schneider et al., "Cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis", KIDNEY INT, 55(2), 1999, pp. 430-441

Abstract

Background. Monocyte chemoattractant protein-1 (MCP-1) has been shown to play a significant role in the recruitment of monocytes/macrophages in experimental glomerulonephritis. Whereas a number of inflammatory mediators havebeen characterized that are involved in the expression of MCP-1 in renal disease, little is known about repressors of chemokine formation in vivo. Wehypothesized that cyclooxygenase (COX) products influence the formation ofMCP-1 and affect inflammatory cell recruitment in glomerulonephritis. Methods. The effect of COX inhibitors was evaluated in the antithymocyte antibody model and an anti-glomerular basement membrane model of glomerulonephritis. Rats were treated with the COX-1/COX-2 inhibitor indomethacin and the selective COX-2 inhibitors meloxicam and SC 58125. Animals were studiedat 1 hour, 24 hours, and 5 days after induction of the disease. Results. Indomethacin, to a lesser degree the selective COX-2 inhibitors, enhanced glomerular MCP-1 and RANTES mRNA levels. Indomethacin enhanced glomerular monocyte chemoattractant activity an the infiltration of monocytes/macrophages at 24 hours and 5 days. Conclusions. Our studies demontrate that COX products may serve as endogenous repressors of MCP-I formation in experimental glomerulonephritis. The data suggest that COX-1 and COX-2 products mediate these effects differentlybecause the selective COX-2 inhibitors had less influence on chemokine expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:20:53