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Titolo:
Synthesis of basement membrane by gastrointestinal cancer cell lines
Autore:
Akashi, T; Miyagi, T; Ando, N; Suzuki, Y; Nemoto, T; Eishi, Y; Nakamura, K; Shirasawa, T; Osa, N; Tanaka, N; Burgeson, RE;
Indirizzi:
Tokyo Med & Dent Univ, Dept Pathol, Bunkyo Ku, Tokyo 113, Japan Tokyo Med & Dent Univ Tokyo Japan 113 athol, Bunkyo Ku, Tokyo 113, Japan Tokyo Metropolitan Inst Gerontol, Dept Mol Pathol, Tokyo, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan t Mol Pathol, Tokyo, Japan PCL Japan, Tokyo, Japan PCL Japan Tokyo JapanPCL Japan, Tokyo, Japan Harvard Med Sch, Cutaneous Biol Ctr, Charleston, MA USA Harvard Med Sch Charleston MA USA Cutaneous Biol Ctr, Charleston, MA USA
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 187, anno: 1999,
pagine: 223 - 228
SICI:
0022-3417(199901)187:2<223:SOBMBG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCAN; IV COLLAGEN; DEVELOPING INTESTINE; GASTRIC-CARCINOMA; LAMININ; EXPRESSION; BINDING; CHAIN; LOCALIZATION; INTEGRIN;
Keywords:
gastrointestinal cancer; basement membrane; laminin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Akashi, T Tokyoapan & Dent Univ, Dept Pathol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 113, J Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 113 kyo 113, J
Citazione:
T. Akashi et al., "Synthesis of basement membrane by gastrointestinal cancer cell lines", J PATHOLOGY, 187(2), 1999, pp. 223-228

Abstract

Gastrointestinal adenocarcinoma-derived cell lines mere studied in order to determine their pattern of expression of basement membrane components andtheir ability to form a basement membrane. In contrast to the well-preserved expression of laminin beta 2,beta 3,gamma 1, and gamma 2 chain mRNAs, five of eight gastrointestinal cancer cells lacked alpha 3 mRNA, Immunohistochemical and electron microscopic examination of four cell lines transplanted subcutaneously to SCID mice demonstrated the presence of both alpha 3 andalpha 5 chains and the formation of a basal lamina in two cases. The othertwo cell lines lacked both alpha 3 and alpha 5 chains and could not form abasal lamina, suggesting that this deficiency may be a factor which affects their ability to form a basement membrane. This abnormality might play some role in stromal invasion by tumour cells in gastrointestinal cancer, Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:15:36