Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Kinetic modeling of [Tc-99m]TRODAT-1: A dopamine transporter imaging agent
Autore:
Kushner, SA; McElgin, WT; Kung, MP; Mozley, PD; Plossl, K; Meegalla, SK; Mu, M; Dresel, S; Vessotskie, JM; Lexow, N; Kung, HF;
Indirizzi:
Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 40, anno: 1999,
pagine: 150 - 158
SICI:
0161-5505(199901)40:1<150:KMO[AD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BETA-CIT; HUMAN BRAIN; BENZODIAZEPINE RECEPTORS; SEROTONIN TRANSPORTERS; PARKINSONS-DISEASE; SPECT MEASUREMENT; NUCLEAR-MEDICINE; BABOON BRAIN; BINDING;
Keywords:
striatum; SPECT; dopamine neuron; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kung, HF Univ Penn, Dept Radiol, 3700 Market St,Room 305, Philadelphia, PA19104 USA Univ Penn 3700 Market St,Room 305 Philadelphia PA USA 19104 4 USA
Citazione:
S.A. Kushner et al., "Kinetic modeling of [Tc-99m]TRODAT-1: A dopamine transporter imaging agent", J NUCL MED, 40(1), 1999, pp. 150-158

Abstract

[Tc-99m]Technetium[2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo [3.2.1] oct-2-yl]-methyl] (2-mercaptoethyl) amino] ethyl] amino] ethane-thiolato(3-)-N2,N2',S2,S2']oxo-[1R-(exo-exo)] ([Tc-99m] TRODAT-1) is a useful imaging agent for central nervous system dopamine transporters. The purpose of this study was to characterize the in vivo binding potential and kinetic rate constants of this agent in nonhuman primates. ' Methods: A series of four SPECT scans were performed on each of two female baboons with a bolus injection of [Tc-99m]TRODAT-1 (717 +/- 78 MBq; 19.38 +/- 2.12 mCi). Dynamic images of the brain were acquired over 4 h using a triple-head camera equipped with fan-beam collimators. Arterial and venous blood were sampled frequently using a peristaltic pump throughout the duration of the study. Regions ofinterest were drawn on the corresponding MRI scan to which each functionalimage was coregistered. Using analytical solutions to the three-compartment model with the Levenberg-Marquardt minimization technique, each study wasindividually fitted to a kinetic parameter vector (method I). Additionally, within each subject, three corresponding intrasubject studies were fittedsimultaneously to a single parameter vector by constraining the binding potential, distribution volume and dissociation rate constant to improve the identifiability of the parameter estimates (method II). Results: The results clearly indicated that [Tc-99m] TRODAT-1 localized in the striatum with slower washout rate than other brain regions. A maximal target/nontarget ratio of 3.5 between striatum and cerebellum was obtained. SPECT image analysis of the striatum yielded unconstrained k(3)/k(4), values of 3.4 +/- 1.4, 2.4 +/- 0.7, 3.0 +/- 1.5, and 4.0 +/- 10.3, with respective constrained (fixed k(4)) values of 2.9 +/- 0.4, 2.4 +/- 0.4, 1.7 +/- 0.4 and 1.8 +/- 0.4 inone baboon using method I. With method II, the corresponding simultaneously fitted values were 2.1 +/- 0.3 using no constraints and 2.2 +/- 0.2 usinga fixed k(4) The second baboon had similar results. Conclusion: These findings suggest that the binding potential and corresponding kinetic rate constants can be reliably estimated in nonhuman primates with dynamic SPECT imaging of the dopamine transporter using a technetium-based tropane analogue. Furthermore, method II parameter vectors compare favorably to those produced using method I based on SEEs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:17:04