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Titolo:
Regional cerebral blood flow changes in chronic alcoholic patients inducedby naltrexone challenge during detoxification
Autore:
Catafau, AM; Etcheberrigaray, A; de los Cobos, JP; Estorch, M; Guardia, J; Flotats, A; Berna, L; Mari, C; Casas, M; Carrio, I;
Indirizzi:
Hosp St Pau, Nucl Med Serv, Dept Nucl Med, Barcelona 08025, Spain Hosp St Pau Barcelona Spain 08025 Dept Nucl Med, Barcelona 08025, Spain Hosp St Pau, Addict Behav Unit, Barcelona 08025, Spain Hosp St Pau Barcelona Spain 08025 ict Behav Unit, Barcelona 08025, Spain Univpainonoma Barcelona, Dept Psiquiatria & Med Legal, E-08193 Barcelona, S Univ Autonoma Barcelona Barcelona Spain E-08193 al, E-08193 Barcelona, S
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 40, anno: 1999,
pagine: 19 - 24
SICI:
0161-5505(199901)40:1<19:RCBFCI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTERIZED-TOMOGRAPHY; OBSESSIVE-COMPULSIVE DISORDER; BRAIN GLUCOSE-METABOLISM; BASE-LINE; DEPENDENCE; SPECT; WITHDRAWAL; PERFUSION; NALOXONE; SYSTEM;
Keywords:
SPECT; regional cerebral blood flow; naltrexone; alcoholism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Catafau, AM HospaSt Pau, Nucl Med Serv, Dept Nucl Med, St Antoni M Claret 167, Barcelon Hosp St Pau St Antoni M Claret 167 Barcelona Spain 08025 elon
Citazione:
A.M. Catafau et al., "Regional cerebral blood flow changes in chronic alcoholic patients inducedby naltrexone challenge during detoxification", J NUCL MED, 40(1), 1999, pp. 19-24

Abstract

The recent introduction of the opioid antagonist naltrexone for alcohol-dependence therapy has been mainly based on behavioral animal models that provide evidence of the involvement of the endogenous opioid system in alcoholdrinking and dependence. However, the neurophysiological mechanisms of theeffect of naltrexone in alcoholic patients remain unknown. This study investigates the effects of a naltrexone challenge on regional cerebral blood flow (rCBF) in chronic alcoholic patients during detoxification. Methods: Sixteen alcoholic inpatients underwent two Tc-99m-hexamethyl propyleneamine oxime (HMPAO) brain SPECTs: a basal SPECT on day 10 of abstinence and a second SPECT on day 12 of abstinence after oral administration of 150 mg naltrexone. Region-to-cerebellar ratios were obtained for the orbitary frontal, prefrontal, lateral temporal and mesial temporal regions, basal ganglia and thalamus in each hemisphere, A percentage of rCBF change between both SPECTs was calculated for each region as 100 x (naltrexone - baseline)/ baseline. Values from 13 brain SPECTs of age-matched normal volunteers including test-retest measurements were used for statistical comparison. Results: in baseline conditions, alcoholics showed lower rCBF than controls in left orbitofrontal cortex (84.0 +/- 5.1 versus 89.8 +/- 5.0, P< 0.01) and prefrontal cortex (left hemisphere: 87.4 +/- 5.2 versus 96.2 +/- 3.6, P < 0.001; righthemisphere: 87.0 +/- 4.9 versus 95.8 +/- 4.2, P< 0.001), After naltrexone,a significant rCBF decrease was found Versus test-retest values in left basal ganglia (-3.3% +/- 4.0% versus 1.5% +/- 4.1%, P < 0.05), right basal ganglia (-4.2% +/- 4.9% versus 0.6% +/- 2.7%, P < 0.01) and left mesial temporal region (-4.5% +/- 6.8% versus 2.2% +/- 2.9%, P< 0.01). Conclusion: The rCBF decrease detected by SPECT after naltrexone challenge in structures rich in opioid receptors, such as the basal ganglia and the left mesial temporal region, may reflect a naltrexone-induced decreased metabolic activity in these areas. These results support the involvement of the opioid system in alcohol dependence. Furthermore, the localization of naltrexone-induced rCBF changes in mesial temporal structures and in basal ganglia supports theimplication of emotional memory and obsessive-compulsive phenomena in craving,

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Documento generato il 20/01/20 alle ore 10:33:08